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    Gmppa GDP-mannose pyrophosphorylase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501167, updated on 6-Jun-2024

    Summary

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    Symbol
    Gmppaprovided by RGD
    Full Name
    GDP-mannose pyrophosphorylase Aprovided by RGD
    Primary source
    RGD:1560644
    See related
    Ensembl:ENSRNOG00000019946 AllianceGenome:RGD:1560644
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mannose-1-phosphate guanylyltransferase activity. Predicted to be involved in biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 145.3), Kidney (RPKM 111.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gmppa in Genome Data Viewer
    Location:
    9q33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84375373..84382917)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76926724..76934274)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82632267..82639811)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550477 Neighboring gene desmin Neighboring gene striated muscle enriched protein kinase Neighboring gene uncharacterized LOC120094713 Neighboring gene uncharacterized LOC108351955 Neighboring gene uncharacterized LOC120094714 Neighboring gene acid sensing ion channel subunit family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues. Verachtert H, et al. J Biol Chem, 1966 May 10. PMID 5946626
    2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mannose-1-phosphate guanylyltransferase (GTP) activity TAS
    Traceable Author Statement
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within GDP-mannose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within GDP-mannose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within motor behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within muscle organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within telencephalon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    mannose-1-phosphate guanyltransferase alpha
    Names
    GTP-mannose-1-phosphate guanylyltransferase alpha
    NP_001020227.1
    XP_006245333.1
    XP_063123697.1
    XP_063123698.1
    XP_063123700.1
    XP_063123701.1
    XP_063123702.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025056.1 → NP_001020227.1  mannose-1-phosphate guanyltransferase alpha

      See identical proteins and their annotated locations for NP_001020227.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083763
      UniProtKB/Swiss-Prot
      Q5XIC1
      UniProtKB/TrEMBL
      A0A8I5ZKL2, A6JW33
      Related
      ENSRNOP00000027064.3, ENSRNOT00000027064.5
      Conserved Domains (3) summary
      cd06428
      Location:4 → 261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      COG1208
      Location:1 → 349
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
      cl00160
      Location:289 → 355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      84375373..84382917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245271.4 → XP_006245333.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      See identical proteins and their annotated locations for XP_006245333.1

      UniProtKB/Swiss-Prot
      Q5XIC1
      UniProtKB/TrEMBL
      A0A8I5ZKL2, A6JW33
      Related
      ENSRNOP00000074442.2
      Conserved Domains (3) summary
      cd06428
      Location:4 → 261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      COG1208
      Location:1 → 349
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
      cl00160
      Location:289 → 355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

    2. XM_063267630.1 → XP_063123700.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      UniProtKB/Swiss-Prot
      Q5XIC1
      UniProtKB/TrEMBL
      A0A8I5ZKL2, A6JW33

    3. XM_063267627.1 → XP_063123697.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      UniProtKB/Swiss-Prot
      Q5XIC1
      UniProtKB/TrEMBL
      A0A8I5ZKL2, A6JW33

    4. XM_063267628.1 → XP_063123698.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      UniProtKB/Swiss-Prot
      Q5XIC1
      UniProtKB/TrEMBL
      A0A8I5ZKL2, A6JW33

    5. XM_063267632.1 → XP_063123702.1  mannose-1-phosphate guanyltransferase alpha isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZKL2

    6. XM_063267631.1 → XP_063123701.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      UniProtKB/Swiss-Prot
      Q5XIC1
      UniProtKB/TrEMBL
      A0A8I5ZKL2, A6JW33

    RNA

    1. XR_010054629.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIC1.1 GenPept UniProtKB/Swiss-Prot:Q5XIC1

    Gene LinkOut

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