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    Rufy1 RUN and FYVE domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360521, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rufy1provided by RGD
    Official Full Name
    RUN and FYVE domain containing 1provided by RGD
    Primary source
    RGD:1305099
    See related
    Ensembl:ENSRNOG00000003536 AllianceGenome:RGD:1305099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH2 domain binding activity; SH3 domain binding activity; and identical protein binding activity. Predicted to be involved in protein transport and regulation of endocytosis. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be located in cytosol; endosome; and nuclear speck. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human RUFY1 (RUN and FYVE domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 134.4), Heart (RPKM 123.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (35206801..35251696, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34705741..34750644, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35882805..35927268, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene chibby family member 3 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 Neighboring gene uncharacterized LOC103693320 Neighboring gene uncharacterized LOC120095319

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking. Yang J, et al. J Biol Chem, 2002 Aug 16. PMID 11877430
    2. A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic. Cormont M, et al. Proc Natl Acad Sci U S A, 2001 Feb 13. PMID 11172003, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RUN and FYVE domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100727.1 → NP_001094197.1  RUN and FYVE domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HE22, F1LR42
      Related
      ENSRNOP00000004740.5, ENSRNOT00000004740.6
      Conserved Domains (3) summary
      cd15758
      Location:637 → 707
      FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
      pfam02759
      Location:150 → 273
      RUN; RUN domain
      cl02073
      Location:443 → 588
      DUF3422; Protein of unknown function (DUF3422)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      35206801..35251696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086301.2 → XP_038942229.1  RUN and FYVE domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      TIGR02168
      Location:284 → 540
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15758
      Location:545 → 615
      FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
      pfam02759
      Location:58 → 179
      RUN; RUN domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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