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    Mrnip MRN complex interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497895, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mrnipprovided by RGD
    Official Full Name
    MRN complex interacting proteinprovided by RGD
    Primary source
    RGD:1564036
    See related
    Ensembl:ENSRNOG00000003068 AllianceGenome:RGD:1564036
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564036
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; regulation of double-strand break repair; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be part of Mre11 complex. Predicted to be active in nucleus. Orthologous to human MRNIP (MRN complex interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 224.9), Muscle (RPKM 207.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (35002440..35026555)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34501359..34525474)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35680687..35704685)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 130 Neighboring gene microRNA 340-1 Neighboring gene TBC1 domain family member 9B Neighboring gene uncharacterized LOC120095090 Neighboring gene sequestosome 1 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene leukotriene C4 synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response. Staples CJ, et al. Cell Rep, 2016 Sep 6. PMID 27568553, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Mre11 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MRN complex-interacting protein
    Names
    UPF0544 protein C5orf45 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109030.2 → NP_001102500.2  MRN complex-interacting protein

      See identical proteins and their annotated locations for NP_001102500.2

      Status: PROVISIONAL

      Source sequence(s)
      BC166832
      UniProtKB/TrEMBL
      A0A8I6AKC7, B2RYM4
      Related
      ENSRNOP00000093830.1, ENSRNOT00000111939.1
      Conserved Domains (1) summary
      pfam15749
      Location:9 → 107
      MRNIP; MRN-interacting protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      35002440..35026555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086548.1 → XP_038942476.1  MRN complex-interacting protein isoform X1

      Conserved Domains (1) summary
      pfam15749
      Location:9 → 107
      MRNIP; MRN-interacting protein
    Nucleotide Protein Strain
    Heading Accession and Version

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