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    Creb5 cAMP responsive element binding protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500131, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Creb5provided by RGD
    Official Full Name
    cAMP responsive element binding protein 5provided by RGD
    Primary source
    RGD:1566107
    See related
    Ensembl:ENSRNOG00000008622 AllianceGenome:RGD:1566107
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566107
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and identical protein binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; and white fat cell differentiation. Predicted to act upstream of or within adipose tissue development; fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human CREB5 (cAMP responsive element binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 32.7), Muscle (RPKM 23.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (83723587..84124786)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (82393091..82794320)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (83390782..83840356)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene creatine kinase, mitochondrial 1, pseudogene 1 Neighboring gene uncharacterized LOC120102281 Neighboring gene uncharacterized LOC134486769 Neighboring gene TLR4 interactor with leucine-rich repeats

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA. Zu YL, et al. Oncogene, 1993 Oct. PMID 8378084
    2. Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA. Deng B, et al. Cell Biosci, 2014. PMID 25105010, Free PMC Article
    3. The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. Maekawa T, et al. Mol Cell Biol, 2010 Feb. PMID 19948881, Free PMC Article
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in white fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclic AMP-responsive element-binding protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134621.1 → NP_001128093.1  cyclic AMP-responsive element-binding protein 5

      See identical proteins and their annotated locations for NP_001128093.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474011
      UniProtKB/TrEMBL
      A6K0T7, D3ZBH0
      Related
      ENSRNOP00000036595.4, ENSRNOT00000031365.6
      Conserved Domains (1) summary
      cd14687
      Location:430 → 489
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      83723587..84124786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108137.2 → XP_038964065.1  cyclic AMP-responsive element-binding protein 5 isoform X6

    2. XM_039108135.2 → XP_038964063.1  cyclic AMP-responsive element-binding protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQI5
      Related
      ENSRNOP00000079273.1
      Conserved Domains (1) summary
      cd14687
      Location:377 → 436
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    3. XM_039108134.2 → XP_038964062.1  cyclic AMP-responsive element-binding protein 5 isoform X1

      Conserved Domains (1) summary
      cd14687
      Location:421 → 480
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    4. XM_017592796.3 → XP_017448285.1  cyclic AMP-responsive element-binding protein 5 isoform X3

    5. XM_008762908.4 → XP_008761130.1  cyclic AMP-responsive element-binding protein 5 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K5F0
      Related
      ENSRNOP00000073400.1
      Conserved Domains (1) summary
      cd14687
      Location:238 → 297
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    6. XM_039108136.2 → XP_038964064.1  cyclic AMP-responsive element-binding protein 5 isoform X4

      Conserved Domains (1) summary
      cd14687
      Location:263 → 322
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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