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    Fbxl8 F-box and leucine-rich repeat protein 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498941, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Fbxl8provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 8provided by RGD
    Primary source
    RGD:1566420
    See related
    Ensembl:ENSRNOG00000015242 AllianceGenome:RGD:1566420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566420
    Summary
    Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and entrainment of circadian clock by photoperiod. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human FBXL8 (F-box and leucine rich repeat protein 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 24.1), Thymus (RPKM 20.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl8 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50048221..50057191)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33142705..33147266)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37216696..37225701)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene phagosome assembly factor 1 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene TNFRSF1A-associated via death domain Neighboring gene heat shock transcription factor 4 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene nucleolar protein 3 Neighboring gene exocyst complex component 3-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396452.1 → NP_001383381.1  F-box/LRR-repeat protein 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IYM6
      Conserved Domains (2) summary
      sd00034
      Location:103 → 136
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:5 → 34
      F-box-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50048221..50057191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278190.1 → XP_063134260.1  F-box/LRR-repeat protein 8 isoform X1

      UniProtKB/TrEMBL
      A6IYM6

    2. XM_006255521.5 → XP_006255583.1  F-box/LRR-repeat protein 8 isoform X2

      UniProtKB/TrEMBL
      D3ZYT9
      Related
      ENSRNOP00000020441.4
      Conserved Domains (1) summary
      sd00034
      Location:72 → 105
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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