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    Cpe carboxypeptidase E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25669, updated on 24-Jul-2021

    Summary

    Official Symbol
    Cpeprovided by RGD
    Official Full Name
    carboxypeptidase Eprovided by RGD
    Primary source
    RGD:2394
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cph; CARBE
    Summary
    may play a role in post-translational processing of peptide hormones including preproopiomelanocortin [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 2437.3), Heart (RPKM 767.8) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cpe in Genome Data Viewer
    Location:
    16p13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (25030276..25142231)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (26906716..27014811)

    Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene methylsterol monooxygenase 1 Neighboring gene uncharacterized LOC120097471 Neighboring gene glucocorticoid receptor DNA binding factor 1, pseudogene 1 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC93638

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cobalt ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurexin family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurexin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac left ventricle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac left ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in enkephalin processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within insulin processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of branching morphogenesis of a nerve IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptide hormone processing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peptide hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within peptide hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein localization to secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dense core granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    carboxypeptidase E
    Names
    carboxypeptidase H
    enkephalin convertase
    prohormone-processing carboxypeptidase
    NP_037260.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013128.2NP_037260.2  carboxypeptidase E precursor

      Status: PROVISIONAL

      Source sequence(s)
      JACYVU010000279
      Conserved Domains (2) summary
      cd11308
      Location:375449
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cd03865
      Location:53371
      M14_CPE; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase E subgroup

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

      Range
      25030276..25142231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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