Terf2ip TERF2 interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Terf2ipprovided by RGD
Official Full Name: TERF2 interacting proteinprovided by RGD
Primary source: RGD:1309684
See related: Ensembl:ENSRNOG00000010712 AllianceGenome:RGD:1309684
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable telomeric DNA binding activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of nucleobase-containing compound metabolic process; and telomere maintenance via telomere lengthening. Predicted to be located in chromosome, telomeric region; cytoplasm; and nucleus. Predicted to be part of shelterin complex. Orthologous to human TERF2IP (TERF2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 312.8), Brain (RPKM 150.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (56886211..56893300)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (39976965..39984055)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (44231317..44238406)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rap1 may induce hepatic ischemia reperfusion injury (IRI) through promoting neutrophils inflammatory response. Rap1 may be the potential therapeutic target of attenuating hepatic IRI.
Title: Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-rich strand telomeric DNA binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA recombination at telomere	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA recombination at telomere	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protection from non-homologous end joining at telomere	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in protection from non-homologous end joining at telomere	ISO Inferred from Sequence Orthology more info
NOT involved_in protection from non-homologous end joining at telomere	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in telomere maintenance via telomere lengthening	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomere lengthening	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomere lengthening	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in telomeric loop formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of shelterin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: telomeric repeat-binding factor 2-interacting protein 1

Names: RAP1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; repressor/activator protein 1 homolog; telomeric repeat binding factor 2, interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013143.1 → NP_001013161.1 telomeric repeat-binding factor 2-interacting protein 1

See identical proteins and their annotated locations for NP_001013161.1

Status: PROVISIONAL

Source sequence(s)

BC090335

UniProtKB/Swiss-Prot

Q5EAN7

UniProtKB/TrEMBL

A0A8L2Q715, A6IZC5

Related

ENSRNOP00000085839.1, ENSRNOT00000114583.1

Conserved Domains (3) summary

cd11653
Location:300 → 393

rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres

pfam08914
Location:129 → 193

Myb_DNA-bind_2; Rap1 Myb domain

pfam16589
Location:17 → 100

BRCT_2; BRCT domain, a BRCA1 C-terminus domain