Pdia3 protein disulfide isomerase family A, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdia3provided by RGD
Official Full Name: protein disulfide isomerase family A, member 3provided by RGD
Primary source: RGD:68430
See related: Ensembl:ENSRNOG00000015018 AllianceGenome:RGD:68430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ER60; ERp57; Grp58
Summary: Enables MHC class I protein binding activity; peptidase activity; and protein-disulfide reductase (glutathione) activity. Involved in several processes, including cellular response to nonylphenol; response to benzene; and response to ischemia. Located in several cellular components, including acrosomal vesicle; mitochondrial intermembrane space; and smooth endoplasmic reticulum. Part of TAP complex. Used to study autoimmune hepatitis and irritable bowel syndrome. Biomarker of asphyxia neonatorum; irritable bowel syndrome; liver cirrhosis; post-traumatic stress disorder; and pulmonary hypertension. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 638.3), Spleen (RPKM 616.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (128841781..128865733)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (108388189..108412013)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (113376983..113400707)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons.
Title: Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons.
Riboflavin deficiency affects lipid metabolism partly by reducing apolipoprotein B100 synthesis in rats.
Title: Riboflavin deficiency affects lipid metabolism partly by reducing apolipoprotein B100 synthesis in rats.
VDR and PDIA3/1,25MARRS genes were silenced separately or simultaneously in E16 primary rat cortical neurons
Title: Vitamin D Receptor Regulates Amyloid Beta 1-42 Production with Protein Disulfide Isomerase A3.
Proteomic data revealed significant Pdia-3 expression in microenvironments of osteoarthritis (OA) joint tissue that could be actively responded to extracorporeal shockwave therapy, which may potentially regulate the biological functions of chondrocytes and osteoblasts in the treatment of the early OA of the knee.
Title: Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which Is a Key Factor of the 1α,25-Dihydroxyvitamin D 3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis of the Knee.
it is possible that the vimentin and PDIA3 could be the candidate biomarkers specific to Achyranthes saponin therapy for rheumatoid arthritis in synovial membrane.
Title: Identification of candidate synovial membrane biomarkers after Achyranthes aspera treatment for rheumatoid arthritis.
In Atg7 knock-down INS-1 cells, the suppression of ERp57 expression by siRNA resulted in an increase in the level of cleaved Caspase-3 protein and a decrease in the number of live cells.
Title: Increased expression of ERp57/GRP58 is protective against pancreatic beta cell death caused by autophagic failure.
ERp57 increased between MI and MII oocytes, and concentrated in a dome-shaped area of the microvillar region. Sperm ERp57 localized to the equatorial region of acrosome-reacted sperm. It was needed for penetrating zona pellucida-free oocytes.
Title: Increased expression of ERp57 in rat oocytes during meiotic maturation is associated with sperm-egg fusion.
The results provide some primary information about PDIA3 in testis and sperm for further study on PDIA3 function in rat spermatogenesis and sperm-egg fusion.
Title: Distribution of PDIA3 transcript and protein in rat testis and sperm cells.
ERp57 regulates RalA signalling by acting as a redox-sensitive guanine-nucleotide dissociation inhibitor.
Title: Identification and characterisation of the RalA-ERp57 interaction: evidence for GDI activity of ERp57.
PDIA3 might be potentially involve into the occurence and development of acute rejection response in renal transplantation and increased plasma IL-2, IL-4, IL-6, and CRP levels play an important role to prevent acute kidney allograft rejection in rats.
Title: PDIA3 mRNA expression and IL-2, IL-4, IL-6, and CRP levels of acute kidney allograft rejection in rat.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE107553 (e-PCR)
- UniSTS:246919

Grp58 (e-PCR), detects polymorphism
- UniSTS:143007

RH131986 (e-PCR)
- UniSTS:215269

RH138056 (e-PCR)
- UniSTS:220143

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC class I protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase (glutathione) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-7	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-7	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nonylphenol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin D	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen assembly with MHC class I protein complex	IEA Inferred from Electronic Annotation more info
involved_in peptide antigen assembly with MHC class I protein complex	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to benzene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to genistein	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to leptin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of MHC class I peptide loading complex	IDA Inferred from Direct Assay more info	PubMed
part_of MHC class I peptide loading complex	ISO Inferred from Sequence Orthology more info
part_of TAP complex	IDA Inferred from Direct Assay more info	PubMed
part_of Tapasin-ERp57 complex	IEA Inferred from Electronic Annotation more info
part_of Tapasin-ERp57 complex	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein disulfide-isomerase A3

Names: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; ER protein 57; ER protein 60; ER-60 protease; ERp60; HIP-70; Q-2; disulfide isomerase ER-60; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; glucose regulated protein, 58 kDa; oxidoreductase ERp57; p58; protein disulfide isomerase associated 3

NP_059015.2

EC 5.3.4.1

XP_063139286.1

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017319.2 → NP_059015.2 protein disulfide-isomerase A3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P11598

UniProtKB/TrEMBL

A0A8I6GAH4, A6HPP1

Related

ENSRNOP00000083210.1, ENSRNOT00000113825.1

Conserved Domains (1) summary

TIGR01130
Location:31 → 492

ER_PDI_fam; protein disulfide isomerase, eukaryotic