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    Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24667, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ppm1bprovided by RGD
    Official Full Name
    protein phosphatase, Mg2+/Mn2+ dependent, 1Bprovided by RGD
    Primary source
    RGD:3374
    See related
    AllianceGenome:RGD:3374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pp2c2; PP2C-beta
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including cellular protein modification process; negative regulation of interferon-beta production; and negative regulation of intracellular signal transduction. Predicted to be located in membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in Muscle (RPKM 227.9), Thymus (RPKM 202.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15399559..15460301, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (9646695..9707471, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (8219385..8280127)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479091 Neighboring gene prolyl endopeptidase-like Neighboring gene solute carrier family 3 member 1 Neighboring gene cilia- and flagella-associated protein 251-like Neighboring gene uncharacterized LOC100910809

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monoclonal anti-FLAG antibodies react with a new isoform of rat Mg2+ dependent protein phosphatase beta. Schäfer K, et al. Biochem Biophys Res Commun, 1995 Feb 15. PMID 7532404
    2. Molecular cloning and primary structure of a protein phosphatase 2C isoform. Wenk J, et al. FEBS Lett, 1992 Feb 3. PMID 1312947
    3. PPM1B negatively regulates antiviral response via dephosphorylating TBK1. Zhao Y, et al. Cell Signal, 2012 Nov. PMID 22750291, Free PMC Article
    4. Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules. Kato S, et al. FEBS Lett, 1996 Nov 4. PMID 8915006
    5. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Sun W, et al. Cell Signal, 2009 Jan. PMID 18930133, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-threonine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1B
    NP_001257548.1
    NP_001257549.1
    NP_149087.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270619.2 → NP_001257548.1  protein phosphatase 1B isoform 2

      See identical proteins and their annotated locations for NP_001257548.1

      Status: VALIDATED

      Source sequence(s)
      AJ271837, EV777419, JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K7Q5, A6H9I0, Q6P6W5, Q99ND8
      Conserved Domains (2) summary
      cd00143
      Location:23 → 295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289 → 365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    2. NM_001270620.2 → NP_001257549.1  protein phosphatase 1B isoform 3

      See identical proteins and their annotated locations for NP_001257549.1

      Status: VALIDATED

      Source sequence(s)
      AJ271837, EV777419, JAXUCZ010000006
      UniProtKB/TrEMBL
      A6H9H8, D3ZLY2, Q642F2
      Conserved Domains (2) summary
      cd00143
      Location:23 → 295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289 → 365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    3. NM_033096.3 → NP_149087.1  protein phosphatase 1B isoform 1

      See identical proteins and their annotated locations for NP_149087.1

      Status: VALIDATED

      Source sequence(s)
      AJ271837, EV777419, JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P35815, Q546R0, Q64046
      UniProtKB/TrEMBL
      A6H9H5, A6H9H9
      Conserved Domains (2) summary
      cd00143
      Location:23 → 295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289 → 365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      15399559..15460301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35815.1 GenPept UniProtKB/Swiss-Prot:P35815

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