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    Gale UDP-galactose-4-epimerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114860, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Galeprovided by RGD
    Official Full Name
    UDP-galactose-4-epimeraseprovided by RGD
    Primary source
    RGD:621493
    See related
    Ensembl:ENSRNOG00000009712 AllianceGenome:RGD:621493
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable UDP-glucose 4-epimerase activity and protein homodimerization activity. Predicted to be involved in galactose catabolic process via UDP-galactose. Predicted to act upstream of or within galactose metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in galactose epimerase deficiency. Orthologous to human GALE (UDP-galactose-4-epimerase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 78.0), Lung (RPKM 45.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gale in Genome Data Viewer
    Location:
    5q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153477420..153481926)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148193886..148198392)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154310453..154314959)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene alpha-L-fucosidase 1 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase Neighboring gene lysophospholipase 2 Neighboring gene PITH domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. cDNA from rat cells with reconstitutive galactose-epimerase activity in E. coli. Zeschnigk M, et al. Nucleic Acids Res, 1990 Sep 11. PMID 2205840, Free PMC Article
    2. Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase. Timson DJ. FEBS J, 2005 Dec. PMID 16302980
    3. Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase. Schulz JM, et al. J Biol Chem, 2004 Jul 30. PMID 15175331
    4. Galactitol and galactonate accumulation in heart and skeletal muscle of mice with deficiency of galactose-1-phosphate uridyltransferase. Yager C, et al. Mol Genet Metab, 2004 Feb. PMID 14741191
    5. A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations. Wei X, et al. PLoS Genet, 2014 Dec. PMID 25502805, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine 4-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 4-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose 4-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 4-epimerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in galactose catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in galactose catabolic process via UDP-galactose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose catabolic process via UDP-galactose IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose catabolic process via UDP-galactose ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within galactose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucose 4-epimerase
    Names
    UDP-GalNAc 4-epimerase
    UDP-GlcNAc 4-epimerase
    UDP-N-acetylglucosamine 4-epimerase
    UDP-galactosamine 4-epimerase
    galactose-4-epimerase, UDP
    galactowaldenase
    NP_542961.2
    XP_006239196.1
    XP_038965061.1
    XP_038965062.1
    XP_063143133.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080783.2 → NP_542961.2  UDP-glucose 4-epimerase

      See identical proteins and their annotated locations for NP_542961.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097293
      UniProtKB/Swiss-Prot
      P18645
      UniProtKB/TrEMBL
      A0A9K3Y6V3, F7EKL8, Q4QRB0
      Conserved Domains (1) summary
      cd05247
      Location:4 → 338
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153477420..153481926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287063.1 → XP_063143133.1  UDP-glucose 4-epimerase isoform X4

    2. XM_006239134.5 → XP_006239196.1  UDP-glucose 4-epimerase isoform X2

      See identical proteins and their annotated locations for XP_006239196.1

      UniProtKB/Swiss-Prot
      P18645
      UniProtKB/TrEMBL
      A0A9K3Y6V3, F7EKL8, Q4QRB0
      Related
      ENSRNOP00000013322.6
      Conserved Domains (1) summary
      cd05247
      Location:4 → 338
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

    3. XM_039109133.2 → XP_038965061.1  UDP-glucose 4-epimerase isoform X1

      UniProtKB/Swiss-Prot
      P18645
      Conserved Domains (1) summary
      cd05247
      Location:37 → 371
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

    4. XM_039109134.2 → XP_038965062.1  UDP-glucose 4-epimerase isoform X3

      Conserved Domains (1) summary
      cd05247
      Location:1 → 220
      UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18645.1 GenPept UniProtKB/Swiss-Prot:P18645

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