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    RANBP17 RAN binding protein 17 [ Homo sapiens (human) ]

    Gene ID: 64901, updated on 3-Apr-2024

    Summary

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    Official Symbol
    RANBP17provided by HGNC
    Official Full Name
    RAN binding protein 17provided by HGNC
    Primary source
    HGNC:HGNC:14428
    See related
    Ensembl:ENSG00000204764 MIM:606141; AllianceGenome:HGNC:14428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
    Expression
    Broad expression in testis (RPKM 1.6), thyroid (RPKM 0.5) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5q35.1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (170862018..171300015)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (171402331..171840355)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (170289022..170727019)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170178216-170179100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170179101-170179985 Neighboring gene uncharacterized LOC107986474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170186375-170186905 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170189029-170189559 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170193927-170194791 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170194792-170195655 Neighboring gene uncharacterized LOC107986475 Neighboring gene gamma-aminobutyric acid type A receptor subunit pi Neighboring gene RNA, 7SL, cytoplasmic 623, pseudogene Neighboring gene tubulin epsilon 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170329817-170330318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170330319-170330818 Neighboring gene VISTA enhancer hs608 Neighboring gene VISTA enhancer hs693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170516153-170516720 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170530424-170531252 Neighboring gene uncharacterized LOC124901133 Neighboring gene VISTA enhancer hs278 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:170666590-170667789 Neighboring gene uncharacterized LOC124901217 Neighboring gene USP12 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:170720541-170721740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170734859-170735743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170735744-170736629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170736630-170737514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170737515-170738400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170740171-170741055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170743669-170744244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170744245-170744819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170744820-170745394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170745395-170745969 Neighboring gene ribosomal protein L19 pseudogene 10 Neighboring gene T cell leukemia homeobox 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC. Mandic R, et al. BMC Cancer, 2022 Jul 18. PMID 35850701, Free PMC Article
    2. Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12. Lee JH, et al. J Cell Biochem, 2010 Sep 1. PMID 20503194, Free PMC Article
    3. Identification of a novel putative Ran-binding protein and its close homologue. Koch P, et al. Biochem Biophys Res Commun, 2000 Nov 11. PMID 11071879
    4. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. Kutay U, et al. J Biol Chem, 2000 Dec 22. PMID 11024021
    5. Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Thompson NA, et al. Nat Commun, 2021 Feb 26. PMID 33637726, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC.
      Title: The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC.
    2. These biochemical and functional data reveal RANBP16 and RANBP17 as novel regulators of E2A protein action, and demonstrate specific interaction of E12 with RANBP17.
      Title: Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of RAN binding protein 17 (RANBP17) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32916

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ran-binding protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022897.5 → NP_075048.1  ran-binding protein 17

      See identical proteins and their annotated locations for NP_075048.1

      Status: VALIDATED

      Source sequence(s)
      AC091980, AJ271459, DC404010
      Consensus CDS
      CCDS34287.1
      UniProtKB/Swiss-Prot
      Q8IU74, Q9H2T7
      UniProtKB/TrEMBL
      Q546R4
      Related
      ENSP00000427975.1, ENST00000523189.6
      Conserved Domains (1) summary
      pfam03810
      Location:30 → 95
      IBN_N; Importin-beta N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      170862018..171300015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534627.2 → XP_011532929.1  ran-binding protein 17 isoform X1

      Conserved Domains (1) summary
      pfam03810
      Location:30 → 95
      IBN_N; Importin-beta N-terminal domain

    2. XM_017009738.2 → XP_016865227.1  ran-binding protein 17 isoform X4

    3. XM_017009739.2 → XP_016865228.1  ran-binding protein 17 isoform X5

    4. XM_017009736.2 → XP_016865225.1  ran-binding protein 17 isoform X2

    5. XM_047417530.1 → XP_047273486.1  ran-binding protein 17 isoform X3

    6. XM_017009740.2 → XP_016865229.1  ran-binding protein 17 isoform X6

    7. XM_017009741.3 → XP_016865230.1  ran-binding protein 17 isoform X7

    8. XM_017009742.3 → XP_016865231.1  ran-binding protein 17 isoform X8

    9. XM_017009744.2 → XP_016865233.1  ran-binding protein 17 isoform X9

    10. XM_047417531.1 → XP_047273487.1  ran-binding protein 17 isoform X9

    11. XM_047417532.1 → XP_047273488.1  ran-binding protein 17 isoform X11

    12. XM_011534636.3 → XP_011532938.1  ran-binding protein 17 isoform X12

      UniProtKB/TrEMBL
      Q658U9
      Related
      ENSP00000429298.1, ENST00000519256.5
      Conserved Domains (1) summary
      pfam03810
      Location:30 → 95
      IBN_N; Importin-beta N-terminal domain

    13. XM_011534637.3 → XP_011532939.1  ran-binding protein 17 isoform X14

      UniProtKB/TrEMBL
      Q658U9
      Related
      ENSP00000373770.4, ENST00000389118.8
      Conserved Domains (1) summary
      pfam03810
      Location:30 → 95
      IBN_N; Importin-beta N-terminal domain

    14. XM_017009746.3 → XP_016865235.1  ran-binding protein 17 isoform X13

      UniProtKB/TrEMBL
      Q658U9, Q8IVM9
      Related
      ENSP00000430958.1, ENST00000522066.5
      Conserved Domains (1) summary
      pfam03810
      Location:30 → 95
      IBN_N; Importin-beta N-terminal domain

    15. XM_017009745.2 → XP_016865234.1  ran-binding protein 17 isoform X10

    16. XM_047417533.1 → XP_047273489.1  ran-binding protein 17 isoform X15

    17. XM_017009747.2 → XP_016865236.1  ran-binding protein 17 isoform X16

    RNA

    1. XR_007058628.1 RNA Sequence

    2. XR_941108.3 RNA Sequence

    3. XR_007058630.1 RNA Sequence

    4. XR_007058629.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      171402331..171840355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353158.1 → XP_054209133.1  ran-binding protein 17 isoform X1

    2. XM_054353161.1 → XP_054209136.1  ran-binding protein 17 isoform X4

    3. XM_054353162.1 → XP_054209137.1  ran-binding protein 17 isoform X5

    4. XM_054353159.1 → XP_054209134.1  ran-binding protein 17 isoform X2

    5. XM_054353160.1 → XP_054209135.1  ran-binding protein 17 isoform X3

    6. XM_054353163.1 → XP_054209138.1  ran-binding protein 17 isoform X6

    7. XM_054353164.1 → XP_054209139.1  ran-binding protein 17 isoform X7

    8. XM_054353165.1 → XP_054209140.1  ran-binding protein 17 isoform X8

    9. XM_054353166.1 → XP_054209141.1  ran-binding protein 17 isoform X9

    10. XM_054353168.1 → XP_054209143.1  ran-binding protein 17 isoform X11

    11. XM_054353169.1 → XP_054209144.1  ran-binding protein 17 isoform X12

    12. XM_054353171.1 → XP_054209146.1  ran-binding protein 17 isoform X14

    13. XM_054353170.1 → XP_054209145.1  ran-binding protein 17 isoform X13

      UniProtKB/TrEMBL
      Q8IVM9

    14. XM_054353167.1 → XP_054209142.1  ran-binding protein 17 isoform X10

    15. XM_054353172.1 → XP_054209147.1  ran-binding protein 17 isoform X15

    16. XM_054353173.1 → XP_054209148.1  ran-binding protein 17 isoform X16

    RNA

    1. XR_008487154.1 RNA Sequence

    2. XR_008487156.1 RNA Sequence

    3. XR_008487157.1 RNA Sequence

    4. XR_008487155.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H2T7.1 GenPept UniProtKB/Swiss-Prot:Q9H2T7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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