Hmox1 heme oxygenase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hmox1provided by RGD
Official Full Name: heme oxygenase 1provided by RGD
Primary source: RGD:2806
See related: Ensembl:ENSRNOG00000014117 AllianceGenome:RGD:2806
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ho1; Heox; Hmox; Ho-1; HEOXG; hsp32
Summary: Enables several functions, including heme binding activity; heme oxygenase (decyclizing) activity; and phospholipase D activity. Involved in several processes, including intracellular signal transduction; negative regulation of apoptotic process; and regulation of gene expression. Located in several cellular components, including caveola; endoplasmic reticulum; and nucleolus. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); hepatic vascular disease (multiple); limb ischemia; and sciatic neuropathy. Biomarker of several diseases, including Sjogren's syndrome; artery disease (multiple); brain disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 1679.3), Adrenal (RPKM 142.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (13452365..13479823)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (13466287..13474082)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (14508634..14515455)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exploring the role of Hmox1 in ferroptosis and immune infiltration during renal ischemia-reperfusion injury.
Title: Exploring the role of Hmox1 in ferroptosis and immune infiltration during renal ischemia-reperfusion injury.
Mechanistic insights into the anti-restenotic effects of HSP27 and HO1 modulated by reconstituted HDL on neointimal hyperplasia.
Title: Mechanistic insights into the anti-restenotic effects of HSP27 and HO1 modulated by reconstituted HDL on neointimal hyperplasia.
Heme Oxygenase-1 Alleviates Ischemia-Reperfusion Injury by Inhibiting Hepatocyte Pyroptosis after Liver Transplantation in Rats.
Title: Heme Oxygenase-1 Alleviates Ischemia-Reperfusion Injury by Inhibiting Hepatocyte Pyroptosis after Liver Transplantation in Rats.
Adipose-derived mesenchymal stem cell exosomes ameliorate spinal cord injury in rats by activating the Nrf2/HO-1 pathway and regulating microglial polarization.
Title: Adipose-derived mesenchymal stem cell exosomes ameliorate spinal cord injury in rats by activating the Nrf2/HO-1 pathway and regulating microglial polarization.
Transplantation of endothelial progenitor cells improves myocardial hypertrophy in spontaneously hypertensive rats through HO-1/CREB3/AKT axis.
Title: Transplantation of endothelial progenitor cells improves myocardial hypertrophy in spontaneously hypertensive rats through HO-1/CREB3/AKT axis.
USP7 regulates HMOX-1 via deubiquitination to suppress ferroptosis and ameliorate spinal cord injury in rats.
Title: USP7 regulates HMOX-1 via deubiquitination to suppress ferroptosis and ameliorate spinal cord injury in rats.
MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats.
Title: MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats.
Activation of the NLRP3 inflammasome by HMGB1 through inhibition of the Nrf2/HO-1 pathway promotes bleomycin-induced pulmonary fibrosis after acute lung injury in rats.
Title: Activation of the NLRP3 inflammasome by HMGB1 through inhibition of the Nrf2/HO-1 pathway promotes bleomycin-induced pulmonary fibrosis after acute lung injury in rats.
Donor graft METTL3 gene transfer ameliorates rat liver transplantation ischemia-reperfusion injury by enhancing HO-1 expression in an m[6]A-dependent manner.
Title: Donor graft METTL3 gene transfer ameliorates rat liver transplantation ischemia-reperfusion injury by enhancing HO-1 expression in an m(6)A-dependent manner.
Elevation of HO-1 expression protects the intestinal mucosal barrier in severe acute pancreatitis via inhibition of the MLCK/p-MLC signaling pathway.
Title: Elevation of HO-1 expression protects the intestinal mucosal barrier in severe acute pancreatitis via inhibition of the MLCK/p-MLC signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (523)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d19arb1 (e-PCR)
- UniSTS:121355

RH128180 (e-PCR)
- UniSTS:211488

UniSTS:472912 (e-PCR)
- UniSTS:472912

Hmox1 (e-PCR), detects polymorphism
- UniSTS:472912

d19mit15 (e-PCR)
- UniSTS:120246

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonic acid omega-hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme oxygenase (decyclizing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme oxygenase (decyclizing) activity	IDA Inferred from Direct Assay more info	PubMed
enables heme oxygenase (decyclizing) activity	IEA Inferred from Electronic Annotation more info
enables heme oxygenase (decyclizing) activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to arsenic-containing substance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to arsenic-containing substance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cadmium ion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cisplatin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to cisplatin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in epithelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte homeostasis	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in heme catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heme catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heme catabolic process	ISO Inferred from Sequence Orthology more info
involved_in heme catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heme metabolic process	ISO Inferred from Sequence Orthology more info
involved_in heme oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme oxidation	IEA Inferred from Electronic Annotation more info
involved_in heme oxidation	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
involved_in liver regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macroautophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macroautophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to 3-methylcholanthrene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to arachidonic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in wound healing involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in wound healing involved in inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heme oxygenase 1

Names: heme oxygenase (decycling) 1; heme oxygenase (decyclizing) 1

NP_036712.1

EC 1.14.14.18

XP_038953398.1

EC 1.14.14.18

XP_063133845.1

EC 1.14.14.18

XP_063133846.1

EC 1.14.14.18

XP_063133847.1

EC 1.14.14.18

XP_063133848.1

EC 1.14.14.18

XP_063133849.1

EC 1.14.14.18

XP_063133850.1

EC 1.14.14.18

XP_063133851.1

EC 1.14.14.18

XP_063133852.1

EC 1.14.14.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012580.2 → NP_036712.1 heme oxygenase 1

See identical proteins and their annotated locations for NP_036712.1

Status: PROVISIONAL

Source sequence(s)

BC091164

UniProtKB/Swiss-Prot

P06762, Q5BK87

UniProtKB/TrEMBL

A0A8L2UJE9, A6JY98

Related

ENSRNOP00000019192.5, ENSRNOT00000019192.7

Conserved Domains (2) summary

cd19165
Location:127 → 154

HemeO; kinked helix [structural motif]

pfam01126
Location:11 → 216

Heme_oxygenase; Heme oxygenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

13452365..13479823

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277782.1 → XP_063133852.1 heme oxygenase 1 isoform X1

UniProtKB/Swiss-Prot

P06762, Q5BK87

UniProtKB/TrEMBL

A6JY98
XM_063277781.1 → XP_063133851.1 heme oxygenase 1 isoform X1

UniProtKB/Swiss-Prot

P06762, Q5BK87

UniProtKB/TrEMBL

A6JY98
XM_063277779.1 → XP_063133849.1 heme oxygenase 1 isoform X1

UniProtKB/Swiss-Prot

P06762, Q5BK87

UniProtKB/TrEMBL

A6JY98
XM_063277778.1 → XP_063133848.1 heme oxygenase 1 isoform X1

UniProtKB/Swiss-Prot

P06762, Q5BK87

UniProtKB/TrEMBL

A6JY98
XM_063277780.1 → XP_063133850.1 heme oxygenase 1 isoform X1

UniProtKB/Swiss-Prot

P06762, Q5BK87

UniProtKB/TrEMBL

A6JY98
XM_063277777.1 → XP_063133847.1 heme oxygenase 1 isoform X1

UniProtKB/Swiss-Prot

P06762, Q5BK87

UniProtKB/TrEMBL

A6JY98
XM_063277775.1 → XP_063133845.1 heme oxygenase 1 isoform X1

UniProtKB/Swiss-Prot

P06762, Q5BK87

UniProtKB/TrEMBL

A6JY98
XM_039097470.2 → XP_038953398.1 heme oxygenase 1 isoform X1

UniProtKB/Swiss-Prot

P06762, Q5BK87

UniProtKB/TrEMBL

A0A8L2UJE9, A6JY98

Conserved Domains (2) summary

cd19165
Location:127 → 154

HemeO; kinked helix [structural motif]

pfam01126
Location:11 → 216

Heme_oxygenase; Heme oxygenase
XM_063277776.1 → XP_063133846.1 heme oxygenase 1 isoform X1

UniProtKB/Swiss-Prot

P06762, Q5BK87

UniProtKB/TrEMBL

A6JY98