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    Atp5f1d ATP synthase F1 subunit delta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245965, updated on 26-Jun-2024

    Summary

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    Official Symbol
    Atp5f1dprovided by RGD
    Official Full Name
    ATP synthase F1 subunit deltaprovided by RGD
    Primary source
    RGD:621372
    See related
    Ensembl:ENSRNOG00000014625 AllianceGenome:RGD:621372
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp5d
    Summary
    Contributes to ATP hydrolysis activity. Involved in ATP metabolic process and response to resveratrol. Located in mitochondrial inner membrane. Part of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1). Used to study obesity. Biomarker of colitis and myocardial infarction. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency. Orthologous to human ATP5F1D (ATP synthase F1 subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 508.9), Muscle (RPKM 355.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp5f1d in Genome Data Viewer
    Location:
    7q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10211260..10218989, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9560604..9565919, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12426807..12432120, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cold inducible RNA binding protein Neighboring gene midnolin Neighboring gene CACN subunit beta associated regulatory protein Neighboring gene serine/threonine kinase 11 Neighboring gene uncharacterized LOC134479811

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A combination of resveratrol and quercetin induces browning in white adipose tissue of rats fed an obesogenic diet. Arias N, et al. Obesity (Silver Spring), 2017 Jan. PMID 27874268
    2. Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions. Chen JR, et al. Drug Des Devel Ther, 2015. PMID 26109848, Free PMC Article
    3. Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis. Luan A, et al. Environ Toxicol Pharmacol, 2015 May. PMID 25880160
    4. Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-κB/PGC-1α signaling mediated energy biosynthesis. Zhang S, et al. PLoS One, 2015. PMID 25738576, Free PMC Article
    5. ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury. He K, et al. Am J Physiol Heart Circ Physiol, 2014 Dec 15. PMID 25305180

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aerobic respiration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in proton motive force-driven mitochondrial ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to resveratrol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial proton-transporting ATP synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit delta, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
    F-ATPase delta subunit
    NP_620806.2
    XP_006240907.1
    XP_063119057.1
    XP_063119058.1
    XP_063119059.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139106.2 → NP_620806.2  ATP synthase subunit delta, mitochondrial precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P35434
      UniProtKB/TrEMBL
      A6K8Q6
      Conserved Domains (1) summary
      cd12152
      Location:38 → 162
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10211260..10218989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262988.1 → XP_063119058.1  ATP synthase subunit delta, mitochondrial isoform X1

      UniProtKB/TrEMBL
      G3V7Y3

    2. XM_006240845.4 → XP_006240907.1  ATP synthase subunit delta, mitochondrial isoform X1

      UniProtKB/TrEMBL
      G3V7Y3
      Related
      ENSRNOP00000020670.2
      Conserved Domains (2) summary
      cd12152
      Location:99 → 223
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit
      COG0355
      Location:98 → 228
      AtpC; FoF1-type ATP synthase, epsilon subunit [Energy production and conversion]

    3. XM_063262989.1 → XP_063119059.1  ATP synthase subunit delta, mitochondrial isoform X1

      UniProtKB/TrEMBL
      G3V7Y3

    4. XM_063262987.1 → XP_063119057.1  ATP synthase subunit delta, mitochondrial isoform X1

      UniProtKB/TrEMBL
      G3V7Y3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35434.2 GenPept UniProtKB/Swiss-Prot:P35434

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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