Urah urate (5-hydroxyiso-) hydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Urahprovided by RGD
Official Full Name: urate (5-hydroxyiso-) hydrolaseprovided by RGD
Primary source: RGD:1309350
See related: Ensembl:ENSRNOG00000048275 AllianceGenome:RGD:1309350
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309350
Summary: Predicted to enable hydroxyisourate hydrolase activity. Predicted to be involved in purine nucleobase metabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 898.2), Spleen (RPKM 68.2) and 1 other tissue See more
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Genomic context

Location:: 1q41

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205335399..205338795)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (195905763..195909159)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (213577202..213580598)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydroxyisourate hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in purine nucleobase metabolic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 5-hydroxyisourate hydrolase

NP_001127979.1

EC 3.5.2.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134507.1 → NP_001127979.1 5-hydroxyisourate hydrolase

See identical proteins and their annotated locations for NP_001127979.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A6HXJ9, A6HXK0, D3ZCS9

Related

ENSRNOP00000067773.1, ENSRNOT00000071925.3

Conserved Domains (1) summary

cd05822
Location:29 → 141

TLP_HIUase; HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). ...