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    Pusl1 pseudouridine synthase like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362681, updated on 2-May-2024

    Summary

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    Official Symbol
    Pusl1provided by RGD
    Official Full Name
    pseudouridine synthase like 1provided by RGD
    Primary source
    RGD:1559560
    See related
    Ensembl:ENSRNOG00000022354 AllianceGenome:RGD:1559560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable pseudouridine synthase activity. Predicted to be involved in tRNA pseudouridine synthesis. Predicted to be located in mitochondrion. Orthologous to human PUSL1 (pseudouridine synthase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 88.9), Lung (RPKM 88.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pusl1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171773284..171782893, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166497643..166500647, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173326755..173339934, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste 1 receptor member 3 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel epithelial 1 delta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA pseudouridine(38-40) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA pseudouridine synthase-like 1
    Names
    pseudouridylate synthase-like 1
    NP_001382537.1
    NP_001382538.1
    XP_063144165.1
    XP_063144166.1
    XP_063144167.1
    XP_063144168.1
    XP_063144169.1
    XP_063144170.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395608.1 → NP_001382537.1  tRNA pseudouridine synthase-like 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K730
      Related
      ENSRNOP00000074040.2, ENSRNOT00000078453.2
      Conserved Domains (1) summary
      cd02570
      Location:18 → 284
      PseudoU_synth_EcTruA; Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA

    2. NM_001395609.1 → NP_001382538.1  tRNA pseudouridine synthase-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Conserved Domains (1) summary
      cl00130
      Location:18 → 234
      PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171773284..171782893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288097.1 → XP_063144167.1  tRNA pseudouridine synthase-like 1 isoform X3

    2. XM_063288096.1 → XP_063144166.1  tRNA pseudouridine synthase-like 1 isoform X2

    3. XM_063288100.1 → XP_063144170.1  tRNA pseudouridine synthase-like 1 isoform X6

    4. XM_063288099.1 → XP_063144169.1  tRNA pseudouridine synthase-like 1 isoform X5

    5. XM_063288095.1 → XP_063144165.1  tRNA pseudouridine synthase-like 1 isoform X1

    6. XM_063288098.1 → XP_063144168.1  tRNA pseudouridine synthase-like 1 isoform X4

    RNA

    1. XR_010066443.1 RNA Sequence

    2. XR_010066442.1 RNA Sequence

    3. XR_010066441.1 RNA Sequence

    4. XR_010066444.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108699.1: Suppressed sequence

      Description
      NM_001108699.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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