Ctla4 cytotoxic T-lymphocyte-associated protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctla4provided by RGD
Official Full Name: cytotoxic T-lymphocyte-associated protein 4provided by RGD
Primary source: RGD:61975
See related: Ensembl:ENSRNOG00000054129 AllianceGenome:RGD:61975
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd152; CTLA-4; sCTLA4
Summary: Predicted to enable signaling receptor activity. Involved in negative regulation of T cell proliferation and negative regulation of immune response. Predicted to be located in Golgi apparatus; clathrin-coated endocytic vesicle; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in external side of plasma membrane. Used to study myocarditis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); hepatitis B; kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 27.4), Spleen (RPKM 6.8) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (69812859..69819959)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (62318874..62325978)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (67699397..67706068)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury.
Title: Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury.
Data suggest the potential therapeutic applications for suppression of rheumatoid arthritis (RA) by local joint delivery of CTLA4-FasL.
Title: Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis.
observations indicate that CTLA4-FasL protein represents a significantly suppressive effect on inflammatory fibroblast-like synoviocytes' proliferation
Title: CTLA4-FasL fusion product suppresses proliferation of fibroblast-like synoviocytes and progression of adjuvant-induced arthritis in rats.
The mixed lymphocyte reaction results indicate that ex vivo transfer of AdCTLA4Ig induces antigen-specific unresponsiveness. AdCTLA4Ig perfusion did not change the proportion of CD4+25+Foxp3+ T cells in recipients' spleens.
Title: Ex vivo transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of rapamycin therapy prolongs free flap allograft survival.
Tongbi Mixture 2 can inhibit T lymphocytes through down-regulating the expressions of CD28 and CD152.
Title: [Effects of Tongbi Mixture 2 on expressions of CD28 and CD152 and content of tumor necrosis factor-alpha in peripheral blood in rats with collagen-induced arthritis].
CTLA-4 plays an important suppressive role in T-cell priming and protective immunity in a prime-challenge model of acute bacterial infection.
Title: Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challenge.
Administration of ethyl pyruvate to inhibit HMGB1 or anti-RAGE antibody could significantly decrease expression levels of CTLA-4, Foxp3 on Tregs, and IL-10 production after burns
Title: The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats.
pSNAV-CTLA4Ig effectively expressed CTLA4Ig in liver allografts. CTLA4Ig improved the pathological findings after liver transplantation.
Title: Immunological inhibition of transplanted liver allografts by adeno-associated virus vector encoding CTLA4Ig in rats.
signaling through CTLA-4 is important in maintaining an immunotolerant phenotype in cardiac allografts
Title: CTLA-4 is important in maintaining long-term survival of cardiac allografts.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of regulatory T cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated endocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell adhesion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytotoxic T-lymphocyte protein 4

Names: CD152 antigen; soluble form; transmembrane form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031674.1 → NP_113862.1 cytotoxic T-lymphocyte protein 4 precursor

See identical proteins and their annotated locations for NP_113862.1

Status: PROVISIONAL

Source sequence(s)

U37121

UniProtKB/TrEMBL

A0A096MJE4, A6IPD6, Q62859

Related

ENSRNOP00000073071.1, ENSRNOT00000091237.2

Conserved Domains (2) summary

cd05721
Location:39 → 152

IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

smart00410
Location:43 → 132

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

69812859..69819959

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245036.5 → XP_006245098.1 cytotoxic T-lymphocyte protein 4 isoform X1

See identical proteins and their annotated locations for XP_006245098.1

UniProtKB/TrEMBL

A6IPD7, G3V7D2, Q9Z1A7

Related

ENSRNOP00000069885.1

Conserved Domains (2) summary

cd05721
Location:39 → 152

IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

smart00410
Location:43 → 132

IG_like; Immunoglobulin like