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    Tut7 terminal uridylyl transferase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501515, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Tut7provided by RGD
    Official Full Name
    terminal uridylyl transferase 7provided by RGD
    Primary source
    RGD:1586015
    See related
    Ensembl:ENSRNOG00000016629 AllianceGenome:RGD:1586015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zcchc6
    Summary
    Predicted to enable RNA uridylyltransferase activity and miRNA binding activity. Predicted to be involved in RNA metabolic process; negative regulation of transposition, RNA-mediated; and oocyte maturation. Predicted to be located in cytosol and nucleoplasm. Orthologous to human TUT7 (terminal uridylyl transferase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 220.0), Spleen (RPKM 193.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tut7 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (4854553..4908758)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (4849287..4903542)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (5225854..5279674)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694026 Neighboring gene ribosomal protein S27a, pseudogene 19 Neighboring gene uncharacterized LOC134482802 Neighboring gene iron-sulfur cluster assembly 1 Neighboring gene uncharacterized LOC134482660 Neighboring gene spermatogenesis-associated protein 31D1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The long and short of microRNA. Yates LA, et al. Cell, 2013 Apr 25. PMID 23622238
    2. Efficient RNA polyuridylation by noncanonical poly(A) polymerases. Rissland OS, et al. Mol Cell Biol, 2007 May. PMID 17353264, Free PMC Article
    3. TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms. Kim B, et al. EMBO J, 2015 Jul 2. PMID 25979828, Free PMC Article
    4. mRNA 3' uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome. Morgan M, et al. Nature, 2017 Aug 17. PMID 28792939, Free PMC Article
    5. Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s. Warkocki Z, et al. Cell, 2018 Sep 6. PMID 30122351, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA uridylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uridylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA 3' uridylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    NOT involved_in histone mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polyuridylation-dependent mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrotransposon silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    terminal uridylyltransferase 7
    Names
    zinc finger CCHC-type containing 6
    zinc finger, CCHC domain containing 6
    NP_001413960.1
    XP_006253593.1
    XP_006253594.1
    XP_006253595.1
    XP_008769686.1
    XP_008769687.1
    XP_038952167.1
    XP_038952169.1
    XP_038952171.1
    XP_063132776.1
    XP_063132777.1
    XP_063132778.1
    XP_063132779.1
    XP_063132781.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427031.1 → NP_001413960.1  terminal uridylyltransferase 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6KAG5, D3ZKR9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      4854553..4908758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253531.3 → XP_006253593.1  terminal uridylyltransferase 7 isoform X1

      See identical proteins and their annotated locations for XP_006253593.1

      UniProtKB/TrEMBL
      A6KAG5
      Conserved Domains (6) summary
      cd05402
      Location:1025 → 1142
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:1453 → 1469
      ZnF_C2HC; zinc finger
      COG5260
      Location:983 → 1314
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1370 → 1451
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    2. XM_063276706.1 → XP_063132776.1  terminal uridylyltransferase 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GE00, A6KAG4, A6KAG5

    3. XM_063276707.1 → XP_063132777.1  terminal uridylyltransferase 7 isoform X4

      UniProtKB/TrEMBL
      A6KAG5, D3ZKR9

    4. XM_006253533.4 → XP_006253595.1  terminal uridylyltransferase 7 isoform X1

      See identical proteins and their annotated locations for XP_006253595.1

      UniProtKB/TrEMBL
      A6KAG5
      Conserved Domains (6) summary
      cd05402
      Location:1025 → 1142
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:1453 → 1469
      ZnF_C2HC; zinc finger
      COG5260
      Location:983 → 1314
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1370 → 1451
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    5. XM_063276709.1 → XP_063132779.1  terminal uridylyltransferase 7 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GKH2, A6KAG5

    6. XM_008771464.3 → XP_008769686.1  terminal uridylyltransferase 7 isoform X2

      See identical proteins and their annotated locations for XP_008769686.1

      UniProtKB/TrEMBL
      A0A8I6GE00, A6KAG4, A6KAG5
      Related
      ENSRNOP00000085565.1
      Conserved Domains (4) summary
      cd05402
      Location:1025 → 1142
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:1453 → 1469
      ZnF_C2HC; zinc finger
      pfam03828
      Location:1237 → 1290
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1372 → 1451
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

    7. XM_008771465.3 → XP_008769687.1  terminal uridylyltransferase 7 isoform X4

      See identical proteins and their annotated locations for XP_008769687.1

      UniProtKB/TrEMBL
      A6KAG5, D3ZKR9
      Related
      ENSRNOP00000022373.8
      Conserved Domains (4) summary
      cd05402
      Location:1025 → 1142
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:1453 → 1469
      ZnF_C2HC; zinc finger
      pfam03828
      Location:1237 → 1290
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1372 → 1451
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7

    8. XM_006253532.4 → XP_006253594.1  terminal uridylyltransferase 7 isoform X1

      See identical proteins and their annotated locations for XP_006253594.1

      UniProtKB/TrEMBL
      A6KAG5
      Conserved Domains (6) summary
      cd05402
      Location:1025 → 1142
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:1453 → 1469
      ZnF_C2HC; zinc finger
      COG5260
      Location:983 → 1314
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1370 → 1451
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    9. XM_063276708.1 → XP_063132778.1  terminal uridylyltransferase 7 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GKH2, A6KAG5

    10. XM_039096241.2 → XP_038952169.1  terminal uridylyltransferase 7 isoform X3

      UniProtKB/TrEMBL
      A6KAG5
      Conserved Domains (6) summary
      cd05402
      Location:974 → 1091
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:1402 → 1418
      ZnF_C2HC; zinc finger
      COG5260
      Location:932 → 1263
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam03828
      Location:499 → 548
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1319 → 1400
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 486
      TUTase; TUTase nucleotidyltransferase domain

    11. XM_039096243.2 → XP_038952171.1  terminal uridylyltransferase 7 isoform X6

      UniProtKB/TrEMBL
      A6KAG5
      Conserved Domains (5) summary
      cd05402
      Location:1025 → 1142
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:1347 → 1362
      ZnF_C2HC; zinc finger
      COG5260
      Location:983 → 1314
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain

    12. XM_063276711.1 → XP_063132781.1  terminal uridylyltransferase 7 isoform X7

    13. XM_039096239.2 → XP_038952167.1  terminal uridylyltransferase 7 isoform X1

      UniProtKB/TrEMBL
      A6KAG5
      Conserved Domains (6) summary
      cd05402
      Location:1025 → 1142
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00343
      Location:1453 → 1469
      ZnF_C2HC; zinc finger
      COG5260
      Location:983 → 1314
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam03828
      Location:550 → 599
      PAP_assoc; Cid1 family poly A polymerase
      pfam16631
      Location:1370 → 1451
      TUTF7_u4; Unstructured region 4 on terminal uridylyltransferase 7
      pfam19088
      Location:205 → 539
      TUTase; TUTase nucleotidyltransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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