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    Mafk MAF bZIP transcription factor K [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246760, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mafkprovided by RGD
    Official Full Name
    MAF bZIP transcription factor Kprovided by RGD
    Primary source
    RGD:628633
    See related
    Ensembl:ENSRNOG00000065794 AllianceGenome:RGD:628633
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables RING-like zinc finger domain binding activity; transcription cis-regulatory region binding activity; and transcription coregulator binding activity. Involved in nervous system development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human MAFK (MAF bZIP transcription factor K). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 82.6), Heart (RPKM 79.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19948473..19970351, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14834628..14856414, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16923989..16934706, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene proteasome assembly chaperone 3 Neighboring gene transmembrane protein 184A Neighboring gene uncharacterized LOC102546414 Neighboring gene integrator complex subunit 1 Neighboring gene MICAL-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth. Töröcsik B, et al. J Neurosci, 2002 Oct 15. PMID 12388604, Free PMC Article
    2. Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus. Kotkow KJ, et al. Proc Natl Acad Sci U S A, 1996 Apr 16. PMID 8622968, Free PMC Article
    3. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Itoh K, et al. Biochem Biophys Res Commun, 1997 Jul 18. PMID 9240432
    4. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Nioi P, et al. Mol Cell Biol, 2005 Dec. PMID 16314513, Free PMC Article
    5. Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. Ohta K, et al. Biochem J, 2007 Mar 15. PMID 17083329, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. during early hepatocarcinogenesis, aberrantly expressed MYST histone acetyltransferase 3 may induce glutathione S-transferase placental form expression through the Nrf2-mediated pathway
      Title: Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RING-like zinc finger domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor MafK
    Names
    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K
    v-maf musculoaponeurotic fibrosarcoma oncogene homolog K

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145673.2 → NP_663706.2  transcription factor MafK

      See identical proteins and their annotated locations for NP_663706.2

      Status: PROVISIONAL

      Source sequence(s)
      BC070906
      UniProtKB/TrEMBL
      Q6IRI7, Q8K4B3
      Related
      ENSRNOT00000117128.1
      Conserved Domains (1) summary
      cd14717
      Location:46 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19948473..19970351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089073.2 → XP_038945001.1  transcription factor MafK isoform X1

      UniProtKB/TrEMBL
      Q6IRI7, Q8K4B3
      Conserved Domains (1) summary
      cd14717
      Location:46 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    2. XM_006248915.5 → XP_006248977.1  transcription factor MafK isoform X1

      See identical proteins and their annotated locations for XP_006248977.1

      UniProtKB/TrEMBL
      Q6IRI7, Q8K4B3
      Conserved Domains (1) summary
      cd14717
      Location:46 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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