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    Tnnt3 troponin T3, fast skeletal type [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24838, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tnnt3provided by RGD
    Official Full Name
    troponin T3, fast skeletal typeprovided by RGD
    Primary source
    RGD:3883
    See related
    Ensembl:ENSRNOG00000020332 AllianceGenome:RGD:3883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tnt
    Summary
    Predicted to enable calcium-dependent protein binding activity and cytoskeletal protein binding activity. Predicted to contribute to actin binding activity. Involved in regulation of striated muscle contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 56590.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q41
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (207082014..207099014)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (197652535..197669736)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (215666628..215683628)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene troponin I2, fast skeletal type Neighboring gene synaptotagmin 8 Neighboring gene lymphocyte-specific protein 1 Neighboring gene proline rich 33 Neighboring gene uncharacterized LOC102548505 Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene microRNA 675 Neighboring gene H19 imprinted maternally expressed transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats. Schilder RJ, et al. J Exp Biol, 2011 May 1. PMID 21490260, Free PMC Article
    2. Time-dependent changes in expression of troponin subunit isoforms in unloaded rat soleus muscle. Stevens L, et al. Am J Physiol Cell Physiol, 2002 May. PMID 11940518
    3. Complete nucleotide sequence of the fast skeletal troponin T gene. Alternatively spliced exons exhibit unusual interspecies divergence. Breitbart RE, et al. J Mol Biol, 1986 Apr 5. PMID 3735424
    4. Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene. Breitbart RE, et al. Cell, 1985 May. PMID 2986851
    5. [Doppler ultrasound in monitoring twin pregnancies with early discordant growth]. Behrens O, et al. Z Geburtshilfe Perinatol, 1992 Sep-Oct. PMID 1299083

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Weight-dependent quantitative variation in Tnnt3 alternative splicing appears to be an evolutionarily conserved feature of skeletal muscle.
      Title: Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats.
    2. HU induced profound slow-to-fast isoform transitions of all Tn subunits, although to different extents and with different time courses. This suggests that slow and fast counterparts of Tn subunit isoforms are regulated independently in response to HU.
      Title: Time-dependent changes in expression of troponin subunit isoforms in unloaded rat soleus muscle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tropomyosin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to tropomyosin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tropomyosin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables troponin C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables troponin C binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables troponin C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables troponin I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables troponin I binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables troponin I binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables troponin T binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of striated muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of striated muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of troponin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of troponin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of troponin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    troponin T, fast skeletal muscle
    Names
    fTnT
    fast skeletal muscle troponin T
    tnTf
    troponin T type 3 (skeletal, fast)
    troponin T3, skeletal, fast

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270664.1 → NP_001257593.1  troponin T, fast skeletal muscle isoform 11

      See identical proteins and their annotated locations for NP_001257593.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (11) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY62
      Conserved Domains (1) summary
      pfam00992
      Location:52 → 188
      Troponin

    2. NM_001270665.1 → NP_001257594.1  troponin T, fast skeletal muscle isoform 1

      See identical proteins and their annotated locations for NP_001257594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 represent the longest transcripts and encode the longest isoforms (1 and 2).
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P09739, P09740, Q304F4, Q4PPA0
      UniProtKB/TrEMBL
      A6HY59, A6HY62
      Conserved Domains (1) summary
      pfam00992
      Location:63 → 199
      Troponin

    3. NM_001270666.1 → NP_001257595.1  troponin T, fast skeletal muscle isoform 2

      See identical proteins and their annotated locations for NP_001257595.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) and variant 1 represent the longest transcripts and encode the longest isoforms (2 and 1).
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY61
      Conserved Domains (1) summary
      pfam00992
      Location:63 → 199
      Troponin

    4. NM_001270668.1 → NP_001257597.1  troponin T, fast skeletal muscle isoform 3

      See identical proteins and their annotated locations for NP_001257597.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY61
      Conserved Domains (1) summary
      pfam00992
      Location:52 → 188
      Troponin

    5. NM_001270670.1 → NP_001257599.1  troponin T, fast skeletal muscle isoform 4

      See identical proteins and their annotated locations for NP_001257599.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY61
      Conserved Domains (1) summary
      pfam00992
      Location:57 → 193
      Troponin

    6. NM_001270671.1 → NP_001257600.1  troponin T, fast skeletal muscle isoform 5

      See identical proteins and their annotated locations for NP_001257600.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY62
      Conserved Domains (1) summary
      pfam00992
      Location:57 → 193
      Troponin

    7. NM_001270672.1 → NP_001257601.1  troponin T, fast skeletal muscle isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY62
      Conserved Domains (1) summary
      pfam00992
      Location:54 → 190
      Troponin

    8. NM_001270673.1 → NP_001257602.1  troponin T, fast skeletal muscle isoform 7

      See identical proteins and their annotated locations for NP_001257602.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY62
      Related
      ENSRNOP00000059829.2, ENSRNOT00000066896.5
      Conserved Domains (1) summary
      pfam00992
      Location:58 → 194
      Troponin

    9. NM_001270675.1 → NP_001257604.1  troponin T, fast skeletal muscle isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks two alternate in-frame exons and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY61
      Conserved Domains (1) summary
      pfam00992
      Location:54 → 190
      Troponin

    10. NM_001270676.1 → NP_001257605.1  troponin T, fast skeletal muscle isoform 10

      See identical proteins and their annotated locations for NP_001257605.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks an alternate in-frame exon and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY61
      Conserved Domains (1) summary
      pfam00992
      Location:58 → 194
      Troponin

    11. NM_001270677.1 → NP_001257606.1  troponin T, fast skeletal muscle isoform 12

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (12) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY62
      Conserved Domains (1) summary
      pfam00992
      Location:48 → 183
      Troponin; Troponin

    12. NM_001270678.1 → NP_001257607.1  troponin T, fast skeletal muscle isoform 13

      See identical proteins and their annotated locations for NP_001257607.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) lacks an alternate in-frame exon and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (13) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY61
      Conserved Domains (1) summary
      pfam00992
      Location:59 → 195
      Troponin

    13. NM_031532.2 → NP_113720.1  troponin T, fast skeletal muscle isoform 8

      See identical proteins and their annotated locations for NP_113720.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (8) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CB612473, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY60, A6HY62
      Conserved Domains (1) summary
      pfam00992
      Location:59 → 195
      Troponin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      207082014..207099014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281060.1 → XP_063137130.1  troponin T, fast skeletal muscle isoform X1

    2. XM_063281062.1 → XP_063137132.1  troponin T, fast skeletal muscle isoform X3

    3. XM_063281061.1 → XP_063137131.1  troponin T, fast skeletal muscle isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHY9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09739.2 GenPept UniProtKB/Swiss-Prot:P09739

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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