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    Klhl4 kelch-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 237010, updated on 12-May-2024

    Summary

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    Official Symbol
    Klhl4provided by MGI
    Official Full Name
    kelch-like 4provided by MGI
    Primary source
    MGI:MGI:2442829
    See related
    Ensembl:ENSMUSG00000025597 AllianceGenome:MGI:2442829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B130014A11; C130018J01Rik
    Summary
    Predicted to be located in centriolar satellite. Is expressed in genitourinary system and heart ventricle. Orthologous to human KLHL4 (kelch like family member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 4.2), cortex adult (RPKM 2.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl4 in Genome Data Viewer
    Location:
    X E1; X 49.47 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (113384030..113470826)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (114474333..114561129)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene methionine aminopeptidase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47793 Neighboring gene histone deacetylase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47795 Neighboring gene STARR-seq mESC enhancer starr_47796 Neighboring gene STARR-seq mESC enhancer starr_47797 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene acid phosphatase pseudogene Neighboring gene ring finger and WD repeat domain 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation. Chiu HS, et al. Dev Biol, 2010 Aug 15. PMID 20510229, Free PMC Article
    2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC107454

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290477.1 → NP_001277406.1  kelch-like protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK081937, AK085099, BX005189
      Consensus CDS
      CCDS72423.1
      UniProtKB/TrEMBL
      B1AZQ9, Q6PGA3
      Related
      ENSMUSP00000108998.2, ENSMUST00000113371.8
      Conserved Domains (6) summary
      smart00612
      Location:564 → 610
      Kelch; Kelch domain
      PHA03098
      Location:175 → 691
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:459 → 502
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:171 → 275
      BTB; BTB/POZ domain
      pfam01344
      Location:458 → 503
      Kelch_1; Kelch motif
      pfam07707
      Location:283 → 382
      BACK; BTB And C-terminal Kelch

    2. NM_001290478.1 → NP_001277407.1  kelch-like protein 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK044930, AK081937, AK085099, BX005189
      UniProtKB/TrEMBL
      Q8BLJ6
      Related
      ENSMUSP00000118072.2, ENSMUST00000133447.2
      Conserved Domains (2) summary
      PHA03098
      Location:175 → 664
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:432 → 475
      Kelch; KELCH repeat [structural motif]

    3. NM_172781.2 → NP_766369.2  kelch-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_766369.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK081448, AK081937, BX005189
      Consensus CDS
      CCDS41108.2
      UniProtKB/TrEMBL
      B1AZR0, Q6PGA3
      Related
      ENSMUSP00000038080.6, ENSMUST00000040504.12
      Conserved Domains (6) summary
      smart00612
      Location:570 → 616
      Kelch; Kelch domain
      PHA03098
      Location:175 → 697
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:465 → 508
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:171 → 275
      BTB; BTB/POZ domain
      pfam01344
      Location:464 → 509
      Kelch_1; Kelch motif
      pfam07707
      Location:283 → 382
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      113384030..113470826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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