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    P2ry10 purinergic receptor P2Y, G-protein coupled 10 [ Mus musculus (house mouse) ]

    Gene ID: 78826, updated on 21-Apr-2024

    Summary

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    Official Symbol
    P2ry10provided by MGI
    Official Full Name
    purinergic receptor P2Y, G-protein coupled 10provided by MGI
    Primary source
    MGI:MGI:1926076
    See related
    Ensembl:ENSMUSG00000050921 AllianceGenome:MGI:1926076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2Y10; Lypsr2; 5830408N17Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in thymus primordium. Orthologous to human P2RY10 (P2Y receptor family member 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 15.8), spleen adult (RPKM 5.6) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X D; X 47.43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (106132098..106148580)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (107088492..107104974)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene retrotransposon Gag like 3 Neighboring gene lysophosphatidic acid receptor 4 Neighboring gene STARR-seq mESC enhancer starr_47740 Neighboring gene STARR-positive B cell enhancer ABC_E11054 Neighboring gene STARR-positive B cell enhancer ABC_E11686 Neighboring gene purinergic receptor P2Y, G-protein coupled 10B Neighboring gene prohibitin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Ets factors PU.1 and Spi-B regulate the transcription in vivo of P2Y10, a lymphoid restricted heptahelical receptor. Rao S, et al. J Biol Chem, 1999 Nov 26. PMID 10567398
    2. G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Gurusamy M, et al. Nat Commun, 2021 Nov 23. PMID 34815397, Free PMC Article
    3. GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair. Wang X, et al. Immunity, 2021 Jun 8. PMID 34107271
    4. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Kihara Y, et al. Br J Pharmacol, 2014 Aug. PMID 24602016, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
      Title: G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative P2Y purinoceptor 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357810.1 → NP_001344739.1  putative P2Y purinoceptor 10

      Status: VALIDATED

      Source sequence(s)
      AK020001, AL928594, BE687386
      Consensus CDS
      CCDS30346.1
      UniProtKB/Swiss-Prot
      A2ASC0, Q7TMT1, Q8BFU7
      UniProtKB/TrEMBL
      F6SDQ0
      Related
      ENSMUSP00000113507.2, ENSMUST00000118666.8
      Conserved Domains (2) summary
      cd14964
      Location:25 → 49
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 305
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_172435.4 → NP_766023.1  putative P2Y purinoceptor 10

      See identical proteins and their annotated locations for NP_766023.1

      Status: VALIDATED

      Source sequence(s)
      AL928594
      Consensus CDS
      CCDS30346.1
      UniProtKB/Swiss-Prot
      A2ASC0, Q7TMT1, Q8BFU7
      UniProtKB/TrEMBL
      F6SDQ0
      Related
      ENSMUSP00000061296.4, ENSMUST00000053375.4
      Conserved Domains (2) summary
      cd14964
      Location:25 → 49
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 305
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      106132098..106148580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFU7.1 GenPept UniProtKB/Swiss-Prot:Q8BFU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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