Micb MHC class I polypeptide-related sequence B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Micbprovided by RGD
Official Full Name: MHC class I polypeptide-related sequence Bprovided by RGD
Primary source: RGD:1564508
See related: Ensembl:ENSRNOG00000057645 AllianceGenome:RGD:1564508
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mill2
Summary: Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be involved in several processes, including immune response-activating cell surface receptor signaling pathway; negative regulation of defense response to virus by host; and response to retinoic acid. Predicted to be anchored component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to human MICB (MHC class I polypeptide-related sequence B). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Biased expression in Lung (RPKM 55.7), Adrenal (RPKM 30.9) and 9 other tissues See more
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Genomic context

Location:: 1q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (87623826..87641075)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78495779..78513030)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (79754587..79772092)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables natural killer cell lectin-like receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-delta T cell activation	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response-activating cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: MHC class I-like protein MILL2

Names: MHC I like leukocyte 2; MHC class I-like located near the LRC, 2; MHC class I-like located near the leukocyte receptor complex 2; Mill2 gene for MHC class I-like located near the LRC, 2, exon 3, partial cds, strain:LEW.1lm1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017468.2 → NP_001017468.1 MHC class I-like protein MILL2 precursor

See identical proteins and their annotated locations for NP_001017468.1

Status: VALIDATED

Description

Transcript Variant: This variant (1, coding) represents the functional allele that is not present in some strains, including the strain of the reference genome.

Source sequence(s)

AB113961

UniProtKB/Swiss-Prot

A0A0G2K7V7, Q60I19

Related

ENSRNOP00000074366.2, ENSRNOT00000083211.2

Conserved Domains (2) summary

cl08246
Location:31 → 200

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cl11960
Location:212 → 294

Ig; Immunoglobulin domain

RNA

NR_190833.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1, non-coding) contains a premature stop codon, and represents the non-functional allele present in some strains, including the strain of the reference genome. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, coding, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

JAXUCZ010000001