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    Mynn myoneurin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361924, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Mynnprovided by RGD
    Official Full Name
    myoneurinprovided by RGD
    Primary source
    RGD:1307889
    See related
    Ensembl:ENSRNOG00000027923 AllianceGenome:RGD:1307889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleoplasm. Orthologous to human MYNN (myoneurin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 108.9), Spleen (RPKM 90.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mynn in Genome Data Viewer
    Location:
    2q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (114708150..114726450, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (112779654..112797188, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (116397154..116414702, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 28 Neighboring gene leucine rich repeat containing 31 Neighboring gene leucine-rich repeats and IQ motif containing 4 Neighboring gene leucine rich repeat containing 34 Neighboring gene transfer RNA valine (anticodon AAC) 1 Neighboring gene actin-related protein T3 Neighboring gene telomerase RNA component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle. Alliel PM, et al. Biochem Biophys Res Commun, 2000 Jun 24. PMID 10873615
    2. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC108895

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myoneurin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012178.2 → NP_001012178.1  myoneurin isoform 3

      See identical proteins and their annotated locations for NP_001012178.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      F7F7X6, Q5FVP1
      Conserved Domains (3) summary
      sd00017
      Location:190 → 210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:190 → 210
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:202 → 227
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001399702.1 → NP_001386631.1  myoneurin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2KAA6, A6IHM0, F7F7X6
      Related
      ENSRNOP00000075326.1, ENSRNOT00000078148.2

    3. NM_001399703.1 → NP_001386632.1  myoneurin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6IHM1, F7F7X6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      114708150..114726450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232233.5 → XP_006232295.1  myoneurin isoform X1

      See identical proteins and their annotated locations for XP_006232295.1

      UniProtKB/TrEMBL
      A6IHL9, F7F7X6
      Related
      ENSRNOP00000010344.6
      Conserved Domains (5) summary
      smart00225
      Location:25 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:304 → 324
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:304 → 324
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 115
      BTB; BTB/POZ domain
      pfam13465
      Location:316 → 341
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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