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    Rpl19 ribosomal protein L19 [ Mus musculus (house mouse) ]

    Gene ID: 19921, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rpl19provided by MGI
    Official Full Name
    ribosomal protein L19provided by MGI
    Primary source
    MGI:MGI:98020
    See related
    Ensembl:ENSMUSG00000017404 AllianceGenome:MGI:98020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to act upstream of or within translation. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in cumulus oophorus; early conceptus; oocyte; and ovary. Orthologous to human RPL19 (ribosomal protein L19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 435.4), placenta adult (RPKM 390.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpl19 in Genome Data Viewer
    Location:
    11 D; 11 61.56 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97912829..97921319)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98022003..98030493)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5273 Neighboring gene STARR-positive B cell enhancer ABC_E10711 Neighboring gene nuclear encoded tRNA cysteine 54 (anticodon GCA) Neighboring gene STARR-positive B cell enhancer ABC_E5274 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97861691-97862052 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97864016-97864125 Neighboring gene STARR-positive B cell enhancer ABC_E11491 Neighboring gene ADP-ribosylation factor-like 5C Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E3013 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene STARR-positive B cell enhancer ABC_E9372 Neighboring gene STARR-seq mESC enhancer starr_30655 Neighboring gene STARR-seq mESC enhancer starr_30656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene F-box and leucine-rich repeat protein 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of mouse L19 ribosomal protein cDNA isolated in screening with tre oncogene probes. Nakamura T, et al. DNA Cell Biol, 1990 Dec. PMID 1702292
    2. Microvascular biodistribution of L19-SIP in angiogenesis targeting strategies. Czabanka M, et al. Eur J Cancer, 2011 May. PMID 21396810
    3. Expression of heparan sulfate proteoglycan (perlecan) in the mouse blastocyst is regulated during normal and delayed implantation. Smith SE, et al. Dev Biol, 1997 Apr 1. PMID 9142982
    4. Estrogen receptor and progesterone receptor genes are expressed differentially in mouse embryos during preimplantation development. Hou Q, et al. Proc Natl Acad Sci U S A, 1993 Oct 15. PMID 8415723, Free PMC Article
    5. The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer. Wagner K, et al. Clin Cancer Res, 2008 Aug 1. PMID 18676770

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. L19-SIP shows a time and blood-flow dependent microvascular biodistribution process with angiogenic sprouts as preferential binding sites followed by secondary extravasation of the antibody
      Title: Microvascular biodistribution of L19-SIP in angiogenesis targeting strategies.
    2. L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer
      Title: The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5.8S rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables large ribosomal subunit rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL19
    Names
    60S ribosomal protein L19
    NP_001152955.1
    NP_033104.2
    XP_006532673.1
    XP_030101565.1
    XP_036012353.1
    XP_036012354.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159483.1 → NP_001152955.1  large ribosomal subunit protein eL19 isoform 2

      See identical proteins and their annotated locations for NP_001152955.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' exon and uses a downstream start codon compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AV467392, CB203522
      Consensus CDS
      CCDS48900.1
      UniProtKB/TrEMBL
      A2A547
      Related
      ENSMUSP00000103181.2, ENSMUST00000092425.11
      Conserved Domains (1) summary
      cd01417
      Location:2 → 165
      Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

    2. NM_009078.2 → NP_033104.2  large ribosomal subunit protein eL19 isoform 1

      See identical proteins and their annotated locations for NP_033104.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AV467392, BC089549, BU524941
      Consensus CDS
      CCDS25337.1
      UniProtKB/Swiss-Prot
      P84099
      UniProtKB/TrEMBL
      Q5I0T8
      Related
      ENSMUSP00000017548.7, ENSMUST00000017548.7
      Conserved Domains (1) summary
      cd01417
      Location:4 → 167
      Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97912829..97921319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532610.4 → XP_006532673.1  large ribosomal subunit protein eL19 isoform X2

      See identical proteins and their annotated locations for XP_006532673.1

      UniProtKB/TrEMBL
      A2A547
      Conserved Domains (1) summary
      cd01417
      Location:2 → 165
      Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

    2. XM_030245705.1 → XP_030101565.1  large ribosomal subunit protein eL19 isoform X2

      UniProtKB/TrEMBL
      A2A547
      Conserved Domains (1) summary
      cd01417
      Location:2 → 165
      Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

    3. XM_036156460.1 → XP_036012353.1  large ribosomal subunit protein eL19 isoform X1

      UniProtKB/Swiss-Prot
      P84099
      UniProtKB/TrEMBL
      Q5I0T8
      Conserved Domains (1) summary
      cd01417
      Location:4 → 167
      Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

    4. XM_036156461.1 → XP_036012354.1  large ribosomal subunit protein eL19 isoform X1

      UniProtKB/Swiss-Prot
      P84099
      UniProtKB/TrEMBL
      Q5I0T8
      Conserved Domains (1) summary
      cd01417
      Location:4 → 167
      Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84099.1 GenPept UniProtKB/Swiss-Prot:P84099

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