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    Pin4 peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin) [ Mus musculus (house mouse) ]

    Gene ID: 69713, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pin4provided by MGI
    Official Full Name
    peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin)provided by MGI
    Primary source
    MGI:MGI:1916963
    See related
    Ensembl:ENSMUSG00000079480 AllianceGenome:MGI:1916963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EPVH; Par14; 2410002I22Rik
    Summary
    Predicted to enable bent DNA binding activity and double-stranded DNA binding activity. Predicted to be involved in rRNA processing. Predicted to be located in several cellular components, including mitochondrial matrix; nuclear lumen; and spindle. Predicted to be part of preribosome. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 25.4), CNS E11.5 (RPKM 21.7) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X D; X 45.14 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (101163075..101171276)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (102119469..102127673)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene NHS like 2 Neighboring gene predicted gene, 25828 Neighboring gene STARR-seq mESC enhancer starr_47665 Neighboring gene STARR-seq mESC enhancer starr_47666 Neighboring gene retrotransposon Gag like 5 Neighboring gene STARR-positive B cell enhancer ABC_E5732 Neighboring gene STARR-positive B cell enhancer ABC_E2538 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene excision repair cross-complementing rodent repair deficiency complementation group 6 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding. Surmacz TA, et al. J Mol Biol, 2002 Aug 9. PMID 12144781
    2. Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions. Zhang J, et al. J Biol Chem, 2013 Jul 12. PMID 23720771, Free PMC Article
    3. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate the association of Par14 with insulin receptor substrate 1 (IRS-1) in human HepG2 cells overexpressing both as well as endogenously in the mouse liver.
      Title: Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bent DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of preribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
    Names
    PPIase Pin4
    parvulin-14
    peptidyl-prolyl cis-trans isomerase Pin4
    protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
    rotamase Pin4
    NP_001352019.1
    NP_081457.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365090.2 → NP_001352019.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL807784
      Related
      ENSMUST00000144367.2
      Conserved Domains (1) summary
      cl29122
      Location:4 → 80
      Rotamase_2; PPIC-type PPIASE domain

    2. NM_027181.3 → NP_081457.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1

      See identical proteins and their annotated locations for NP_081457.1

      Status: VALIDATED

      Source sequence(s)
      AL807784
      Consensus CDS
      CCDS41082.1
      UniProtKB/Swiss-Prot
      Q0VE57, Q9CWW6
      Related
      ENSMUSP00000109257.4, ENSMUST00000113627.4
      Conserved Domains (1) summary
      cl29122
      Location:30 → 131
      Rotamase_2; PPIC-type PPIASE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      101163075..101171276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWW6.1 GenPept UniProtKB/Swiss-Prot:Q9CWW6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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