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    Setd5 SET domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 72895, updated on 12-May-2024

    Summary

    Official Symbol
    Setd5provided by MGI
    Official Full Name
    SET domain containing 5provided by MGI
    Primary source
    MGI:MGI:1920145
    See related
    Ensembl:ENSMUSG00000034269 AllianceGenome:MGI:1920145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1757; C330007C20; 2900045N06Rik
    Summary
    Enables histone methyltransferase activity (H3-K36 specific) and histone methyltransferase activity (H3-K9 specific). Involved in several processes, including histone H3-K36 trimethylation; regulation of DNA-templated transcription, elongation; and regulation of histone acetylation. Located in euchromatin and nucleus. Part of Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 23. Orthologous to human SETD5 (SET domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 17.8), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Setd5 in Genome Data Viewer
    Location:
    6 E3; 6 52.73 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113054326..113130393)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113077262..113153432)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene THUMP domain containing 3 Neighboring gene gene trap ROSA 26, Philippe Soriano Neighboring gene STARR-seq mESC enhancer starr_17032 Neighboring gene predicted gene, 22591 Neighboring gene STARR-seq mESC enhancer starr_17033 Neighboring gene lipoma HMGIC fusion partner-like protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E683 Neighboring gene myotubularin related protein 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10707, MGC90828

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables histone H3 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K36 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K36 trimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K9 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K9 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Set3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase SETD5
    Names
    SET domain-containing protein 5
    NP_082661.1
    NP_766593.1
    XP_006506740.1
    XP_011239782.1
    XP_011239784.1
    XP_011239786.1
    XP_011239787.1
    XP_017177260.1
    XP_017177261.1
    XP_030111467.1
    XP_030111468.1
    XP_030111469.1
    XP_030111470.1
    XP_030111471.1
    XP_030111472.1
    XP_030111473.1
    XP_030111474.1
    XP_030111476.1
    XP_030111477.1
    XP_030111478.1
    XP_030111480.1
    XP_030111481.1
    XP_030111482.1
    XP_030111483.1
    XP_030111484.1
    XP_036008223.1
    XP_036008224.1
    XP_036008225.1
    XP_036008226.1
    XP_036008227.1
    XP_036008228.1
    XP_036008229.1
    XP_036008230.1
    XP_036008231.1
    XP_036008232.1
    XP_036008233.1
    XP_036008234.1
    XP_036008235.1
    XP_036008236.1
    XP_036008237.1
    XP_036008238.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028385.1NP_082661.1  histone-lysine N-methyltransferase SETD5 isoform 1

      See identical proteins and their annotated locations for NP_082661.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      AK122551
      Consensus CDS
      CCDS20411.1
      UniProtKB/Swiss-Prot
      Q5XJV7, Q80T94, Q8BKD5, Q8BX30
      Related
      ENSMUSP00000047398.6, ENSMUST00000042889.12
      Conserved Domains (1) summary
      smart00317
      Location:286395
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    2. NM_173005.1NP_766593.1  histone-lysine N-methyltransferase SETD5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2 which has a longer N-terminus compared to isoform 1.
      Source sequence(s)
      AK053541, BC083184, BE446905, BF456249
      Consensus CDS
      CCDS90096.1
      UniProtKB/Swiss-Prot
      Q5XJV7
      Related
      ENSMUSP00000108780.2, ENSMUST00000113155.2
      Conserved Domains (1) summary
      cd19181
      Location:285434
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113054326..113130393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241485.4XP_011239787.1  histone-lysine N-methyltransferase SETD5 isoform X6

      See identical proteins and their annotated locations for XP_011239787.1

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    2. XM_011241480.4XP_011239782.1  histone-lysine N-methyltransferase SETD5 isoform X1

      See identical proteins and their annotated locations for XP_011239782.1

      Conserved Domains (1) summary
      cd19181
      Location:292441
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    3. XM_011241482.4XP_011239784.1  histone-lysine N-methyltransferase SETD5 isoform X2

      UniProtKB/Swiss-Prot
      Q5XJV7
      Related
      ENSMUSP00000108782.2, ENSMUST00000113157.8
      Conserved Domains (1) summary
      cd19181
      Location:285434
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    4. XM_030255607.2XP_030111467.1  histone-lysine N-methyltransferase SETD5 isoform X3

      Conserved Domains (1) summary
      cd19181
      Location:273422
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    5. XM_030255620.2XP_030111480.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    6. XM_036152332.1XP_036008225.1  histone-lysine N-methyltransferase SETD5 isoform X1

      Conserved Domains (1) summary
      cd19181
      Location:292441
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    7. XM_030255612.2XP_030111472.1  histone-lysine N-methyltransferase SETD5 isoform X4

      Conserved Domains (1) summary
      cd19181
      Location:247396
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    8. XM_036152333.1XP_036008226.1  histone-lysine N-methyltransferase SETD5 isoform X2

      Conserved Domains (1) summary
      cd19181
      Location:285434
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    9. XM_036152331.1XP_036008224.1  histone-lysine N-methyltransferase SETD5 isoform X1

      Conserved Domains (1) summary
      cd19181
      Location:292441
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    10. XM_030255613.2XP_030111473.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    11. XM_036152340.1XP_036008233.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    12. XM_030255614.2XP_030111474.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    13. XM_036152338.1XP_036008231.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    14. XM_036152336.1XP_036008229.1  histone-lysine N-methyltransferase SETD5 isoform X4

      Conserved Domains (1) summary
      cd19181
      Location:247396
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    15. XM_036152330.1XP_036008223.1  histone-lysine N-methyltransferase SETD5 isoform X1

      Conserved Domains (1) summary
      cd19181
      Location:292441
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    16. XM_036152334.1XP_036008227.1  histone-lysine N-methyltransferase SETD5 isoform X3

      Conserved Domains (1) summary
      cd19181
      Location:273422
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    17. XM_036152339.1XP_036008232.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    18. XM_030255622.2XP_030111482.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    19. XM_030255609.2XP_030111469.1  histone-lysine N-methyltransferase SETD5 isoform X4

      Conserved Domains (1) summary
      cd19181
      Location:247396
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    20. XM_006506677.5XP_006506740.1  histone-lysine N-methyltransferase SETD5 isoform X1

      See identical proteins and their annotated locations for XP_006506740.1

      Conserved Domains (1) summary
      cd19181
      Location:292441
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    21. XM_030255617.2XP_030111477.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    22. XM_030255621.2XP_030111481.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    23. XM_011241484.4XP_011239786.1  histone-lysine N-methyltransferase SETD5 isoform X4

      Conserved Domains (1) summary
      cd19181
      Location:247396
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    24. XM_036152341.1XP_036008234.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    25. XM_036152337.1XP_036008230.1  histone-lysine N-methyltransferase SETD5 isoform X5

      Conserved Domains (1) summary
      cd19181
      Location:228377
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    26. XM_017321772.3XP_017177261.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    27. XM_017321771.3XP_017177260.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    28. XM_030255616.2XP_030111476.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    29. XM_036152335.1XP_036008228.1  histone-lysine N-methyltransferase SETD5 isoform X3

      Conserved Domains (1) summary
      cd19181
      Location:273422
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    30. XM_030255611.2XP_030111471.1  histone-lysine N-methyltransferase SETD5 isoform X4

      Conserved Domains (1) summary
      cd19181
      Location:247396
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    31. XM_036152343.1XP_036008236.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    32. XM_036152344.1XP_036008237.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    33. XM_030255608.2XP_030111468.1  histone-lysine N-methyltransferase SETD5 isoform X3

      Conserved Domains (1) summary
      cd19181
      Location:273422
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    34. XM_030255610.2XP_030111470.1  histone-lysine N-methyltransferase SETD5 isoform X4

      Conserved Domains (1) summary
      cd19181
      Location:247396
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    35. XM_030255618.2XP_030111478.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    36. XM_030255623.2XP_030111483.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    37. XM_030255624.2XP_030111484.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    38. XM_036152345.1XP_036008238.1  histone-lysine N-methyltransferase SETD5 isoform X7

      Conserved Domains (1) summary
      cd19181
      Location:292441
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
    39. XM_036152342.1XP_036008235.1  histone-lysine N-methyltransferase SETD5 isoform X6

      Conserved Domains (1) summary
      cd19181
      Location:155304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins