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    Ttll10 tubulin tyrosine ligase like 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298692, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ttll10provided by RGD
    Official Full Name
    tubulin tyrosine ligase like 10provided by RGD
    Primary source
    RGD:1560839
    See related
    Ensembl:ENSRNOG00000020132 AllianceGenome:RGD:1560839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-glycine ligase activity, elongating. Predicted to be involved in protein polyglycylation. Predicted to be located in axoneme and microtubule cytoskeleton. Orthologous to human TTLL10 (tubulin tyrosine ligase like 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 226.3), Kidney (RPKM 47.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttll10 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171912371..171937733, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166630147..166644114, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173471020..173517783, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 4 Neighboring gene TNF receptor superfamily member 18 Neighboring gene uncharacterized LOC106182250 Neighboring gene microRNA 3548 Neighboring gene microRNA 200a Neighboring gene microRNA 429 Neighboring gene microRNA 200b Neighboring gene similar to human chromosome 1 open reading frame 159 Neighboring gene ring finger protein 223

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Rogowski K, et al. Cell, 2009 Jun 12. PMID 19524510
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on a protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein-glycine ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-glycine ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-glycine ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-glycine ligase activity, elongating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glycine ligase activity, elongating ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-glycine ligase activity, elongating ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyglycylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein polyglycylase TTLL10
    Names
    tubulin tyrosine ligase-like family, member 10
    tubulin--tyrosine ligase-like protein 10
    NP_001019929.1
    NP_001164004.1
    XP_006239624.1
    XP_063143579.1
    XP_063143580.1
    XP_063143581.1
    XP_063143582.1
    XP_063143583.1
    XP_063143584.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024758.2 → NP_001019929.1  protein polyglycylase TTLL10 isoform 2

      See identical proteins and their annotated locations for NP_001019929.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BC097417, CK653520
      UniProtKB/TrEMBL
      A0A8L2QPH6
      Conserved Domains (1) summary
      cl17255
      Location:107 → 407
      ATP-grasp_4; ATP-grasp domain

    2. NM_001170533.1 → NP_001164004.1  protein polyglycylase TTLL10 isoform 1

      See identical proteins and their annotated locations for NP_001164004.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC083833, BC097417, CK653520
      UniProtKB/TrEMBL
      A0A0H2UI23
      Related
      ENSRNOP00000063596.3, ENSRNOT00000064207.4
      Conserved Domains (1) summary
      cl17255
      Location:276 → 576
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171912371..171937733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287510.1 → XP_063143580.1  protein polyglycylase TTLL10 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UI23

    2. XM_063287513.1 → XP_063143583.1  protein polyglycylase TTLL10 isoform X5

      UniProtKB/TrEMBL
      A0A8L2QPH6

    3. XM_063287511.1 → XP_063143581.1  protein polyglycylase TTLL10 isoform X3

      UniProtKB/Swiss-Prot
      Q4V8F2, Q5XI57
      UniProtKB/TrEMBL
      A0A8L2QPH6

    4. XM_063287512.1 → XP_063143582.1  protein polyglycylase TTLL10 isoform X4

      UniProtKB/TrEMBL
      A0A0H2UI23

    5. XM_063287509.1 → XP_063143579.1  protein polyglycylase TTLL10 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UI23

    6. XM_063287514.1 → XP_063143584.1  protein polyglycylase TTLL10 isoform X7

    7. XM_006239562.5 → XP_006239624.1  protein polyglycylase TTLL10 isoform X6

      See identical proteins and their annotated locations for XP_006239624.1

      UniProtKB/TrEMBL
      A0A8L2QPH6
      Conserved Domains (1) summary
      cl17255
      Location:107 → 407
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI57.2 GenPept UniProtKB/Swiss-Prot:Q5XI57

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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