Cartpt CART prepropeptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cartptprovided by RGD
Official Full Name: CART prepropeptideprovided by RGD
Primary source: RGD:2272
See related: Ensembl:ENSRNOG00000017712 AllianceGenome:RGD:2272
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cart
Summary: Predicted to enable neuropeptide hormone activity. Involved in several processes, including adult feeding behavior; circadian regulation of gene expression; and regulation of peptide hormone secretion. Located in extracellular space. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CARTPT (CART prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 49.6) and Adrenal (RPKM 4.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (32989215..32991794, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (31255098..31257452, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (30125249..30127408, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and role of cocaine-amphetamine regulated transcript (CART) in the proliferation of biliary epithelium.
Title: Expression and role of cocaine-amphetamine regulated transcript (CART) in the proliferation of biliary epithelium.
Blockade of the orexin 1-receptors and 'cocaine- and amphetamine-regulated transcript' in the nucleus accumbens shell alters impulse control in rats.
Title: Blockade of the orexin 1-receptors and 'cocaine- and amphetamine-regulated transcript' in the nucleus accumbens shell alters impulse control in rats.
CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats.
Title: CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats.
Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide's Promise.
Title: Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide's Promise.
Cocaine- and amphetamine-regulated transcript peptide promotes reward seeking behavior in socially isolated rats.
Title: Cocaine- and amphetamine-regulated transcript peptide promotes reward seeking behavior in socially isolated rats.
Study proposes that CARTp acting in the rostral ventrolateral medulla may involvement in the cardiovascular regulation either by increases in the blood pressure or by decreases in the baroreflex sensitivity in rats.
Title: Roles of cocaine- and amphetamine-regulated transcript peptide in the rostral ventrolateral medulla in cardiovascular regulation in rats.
impaired CART mRNA expression in the anterior Paraventricular nucleus and Lateral hypothalamic area could be related to the aberrant feeding behaviour of dehydration-induced anorexic rats but not to their deregulated HPT axis function.
Title: Impaired hypothalamic cocaine- and amphetamine-regulated transcript expression in lateral hypothalamic area and paraventricular nuclei of dehydration-induced anorexic rats.
The results indicate that Cocaine and Amphetamine-Regulated Transcript (CART) can directly affect the physiological release of hormones in pituitary cells of starved animals.
Title: The effect of CART on pituitary hormones release from cultured pituitary cells harvested from fasted and fed ad libitum male rats.
As the observed results are in agreement with data regarding the CART mRNA and protein expression in the brain reward pathway in opioid addiction phases, it may be suggested that evaluation of CART peptide level in CSF or plasma could be a suitable marker which reflects the rises and falls of the peptide concentration in brain in the development of opioid addiction
Title: Evaluation of CART peptide level in rat plasma and CSF: Possible role as a biomarker in opioid addiction.
Results suggest that CART plays an important role in recognition memory and that these effects may be mediated by NMDA receptors-ERK signaling in the entorhinal/perirhinal -hippocampal circuit.
Title: Pro-cognitive action of CART is mediated via ERK in the hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (118)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adult feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in adult feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in gastric acid secretion	TAS Traceable Author Statement more info	PubMed
involved_in intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of appetite	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of appetite	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucagon secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epinephrine secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transmission of nerve impulse	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in somatostatin secretion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cocaine- and amphetamine-regulated transcript protein

Names: cocaine and amphetamine regulated transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017110.1 → NP_058806.1 cocaine- and amphetamine-regulated transcript protein precursor

See identical proteins and their annotated locations for NP_058806.1

Status: PROVISIONAL

Source sequence(s)

U10071

UniProtKB/Swiss-Prot

P49192

UniProtKB/TrEMBL

A6I575

Conserved Domains (1) summary

pfam06373
Location:67 → 129

CART; Cocaine and amphetamine regulated transcript protein (CART)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

32989215..32991794 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231843.5 → XP_006231905.1 cocaine- and amphetamine-regulated transcript protein isoform X1

See identical proteins and their annotated locations for XP_006231905.1

UniProtKB/Swiss-Prot

P49192

Related

ENSRNOP00000023869.2

Conserved Domains (1) summary

pfam06373
Location:48 → 116

CART; Cocaine and amphetamine regulated transcript protein (CART)