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    Gosr1 golgi SNAP receptor complex member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94189, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gosr1provided by RGD
    Official Full Name
    golgi SNAP receptor complex member 1provided by RGD
    Primary source
    RGD:71093
    See related
    Ensembl:ENSRNOG00000003971 Ensembl:ENSRNOG00000070896 AllianceGenome:RGD:71093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p28; GOS28
    Summary
    Predicted to enable SNAP receptor activity. Acts upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport. Located in cis-Golgi network. Is integral component of membrane. Orthologous to human GOSR1 (golgi SNAP receptor complex member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 122.3), Adrenal (RPKM 113.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (62068662..62105442, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (61570499..61607287, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63405526..63442257)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix family, member a9 Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1 Neighboring gene high mobility group nucleosome binding domain 1, pseudogene 5 Neighboring gene uncharacterized LOC134480825 Neighboring gene carboxypeptidase D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport. Subramaniam VN, et al. Science, 1996 May 24. PMID 8638159
    2. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. Zhong W, et al. Exp Cell Res, 2011 Oct 1. PMID 21669198
    3. Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins. Tang BL, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464276
    4. RNA interference-mediated silencing of the syntaxin 5 gene induces Golgi fragmentation but capable of transporting vesicles. Suga K, et al. FEBS Lett, 2005 Aug 15. PMID 16081076
    5. GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28. Sagiv Y, et al. EMBO J, 2000 Apr 3. PMID 10747018, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport.
      Title: GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inter-Golgi cisterna vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi medial cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Golgi SNAP receptor complex member 1
    Names
    28 kDa Golgi SNARE protein
    28 kDa cis-Golgi SNARE p28
    GOS-28
    cis-Golgi p28 (p28)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053584.2 → NP_446036.1  Golgi SNAP receptor complex member 1

      See identical proteins and their annotated locations for NP_446036.1

      Status: VALIDATED

      Source sequence(s)
      CA338781, CA512572, CB583047, CB712832, CB789285, U49099
      UniProtKB/Swiss-Prot
      A0JN01, Q62931
      UniProtKB/TrEMBL
      A0A8I6A6P3, A6HGW3
      Related
      ENSRNOP00000090076.1, ENSRNOT00000077038.2
      Conserved Domains (1) summary
      cd15864
      Location:160 → 225
      SNARE_GS28; SNARE motif of GS28

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      62068662..62105442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246914.4 → XP_006246976.1  Golgi SNAP receptor complex member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6P3
      Conserved Domains (1) summary
      cd15864
      Location:158 → 223
      SNARE_GS28; SNARE motif of GS28

    2. XM_008768132.4 → XP_008766354.1  Golgi SNAP receptor complex member 1 isoform X2

      Related
      ENSRNOP00000068434.2
      Conserved Domains (1) summary
      cd15864
      Location:95 → 160
      SNARE_GS28; SNARE motif of GS28
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62931.1 GenPept UniProtKB/Swiss-Prot:Q62931

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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