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    Fndc1 fibronectin type III domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308099, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Fndc1provided by RGD
    Official Full Name
    fibronectin type III domain containing 1provided by RGD
    Primary source
    RGD:1310640
    See related
    Ensembl:ENSRNOG00000030210 AllianceGenome:RGD:1310640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Acts upstream of or within several processes, including cellular response to hypoxia; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of protein phosphorylation. Located in cell-cell junction; mitochondrial membrane; and plasma membrane. Orthologous to human FNDC1 (fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 96.5), Heart (RPKM 66.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fndc1 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49686856..49769263)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (47281839..47364247)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47605211..47687499)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551987 Neighboring gene trans-2,3-enoyl-CoA reductase like 2 Neighboring gene uncharacterized LOC134484863 Neighboring gene uncharacterized LOC103690969 Neighboring gene ATP synthase F1 subunit gamma, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alterations in Fibronectin Type III Domain Containing 1 Protein Gene Are Associated with Hypertension. Deng AY, et al. PLoS One, 2016. PMID 27064407, Free PMC Article
    2. Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma. Sato M, et al. Proc Natl Acad Sci U S A, 2006 Jan 17. PMID 16407149, Free PMC Article
    3. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). Sato M, et al. J Biol Chem, 2009 Nov 6. PMID 19723622, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in Fndc1 gene is associated with Hypertension.
      Title: Alterations in Fibronectin Type III Domain Containing 1 Protein Gene Are Associated with Hypertension.
    2. AGS8 is required for hypoxia-induced apoptosis of ardiomyocytes.
      Title: Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43).
    3. Activator of G protein signaling 8 (AGS8, KIAA1866) has been isolated from a rat heart model of repetitive transient ischemia. AGS8 appears to promote G protein signaling by a mechanism that involves direct interaction with G-protein betagamma [AGS8]
      Title: Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibronectin type III domain-containing protein 1
    Names
    activator of G-protein signaling 8
    fibronectin type III domain containing 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038615.2 → NP_001033704.2  fibronectin type III domain-containing protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q2Q0I9
      UniProtKB/TrEMBL
      A0A128DZ42
      Related
      ENSRNOP00000029878.4, ENSRNOT00000034842.5

    2. NM_001412560.1 → NP_001399489.1  fibronectin type III domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K4G5, A0A8I5ZT63
      Related
      ENSRNOP00000073034.1, ENSRNOT00000089458.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      49686856..49769263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288408.1 → XP_063144478.1  fibronectin type III domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLH3

    2. XM_063288404.1 → XP_063144474.1  fibronectin type III domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZT63

    3. XM_063288412.1 → XP_063144482.1  fibronectin type III domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y884

    4. XM_063288417.1 → XP_063144487.1  fibronectin type III domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y884, A0A8I6AMB4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2Q0I9.2 GenPept UniProtKB/Swiss-Prot:Q2Q0I9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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