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    Ctnna2 catenin alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297357, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ctnna2provided by RGD
    Official Full Name
    catenin alpha 2provided by RGD
    Primary source
    RGD:1305060
    See related
    Ensembl:ENSRNOG00000006003 AllianceGenome:RGD:1305060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Catna2
    Summary
    Predicted to enable actin filament binding activity; beta-catenin binding activity; and identical protein binding activity. Predicted to be involved in several processes, including modification of postsynaptic actin cytoskeleton; negative regulation of Arp2/3 complex-mediated actin nucleation; and nervous system development. Predicted to be located in several cellular components, including basolateral plasma membrane; lamellipodium; and postsynaptic density. Predicted to be part of catenin complex. Predicted to be active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density, intracellular component. Predicted to be extrinsic component of postsynaptic membrane and extrinsic component of presynaptic membrane. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human CTNNA2 (catenin alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 205.3) and Testes (RPKM 103.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ctnna2 in Genome Data Viewer
    Location:
    4q33
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (110852265..112001351, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (109294249..110443409, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (107880611..109042724, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L6, pseudogene 15 Neighboring gene U6 spliceosomal RNA Neighboring gene leucine rich repeat transmembrane neuronal 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene U11 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biallelic loss of human CTNNA2, encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration. Schaffer AE, et al. Nat Genet, 2018 Aug. PMID 30013181, Free PMC Article
    2. Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin. Abe K, et al. Nat Neurosci, 2004 Apr. PMID 15034585
    3. Cadherin regulates dendritic spine morphogenesis. Togashi H, et al. Neuron, 2002 Jul 3. PMID 12123610
    4. Differential expression of alpha-E-catenin and alpha-N-catenin in the developing cerebral cortex. Stocker AM, et al. Brain Res, 2006 Feb 16. PMID 16457793
    5. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. Bogaerts S, et al. Exp Cell Res, 2005 Nov 15. PMID 16182284

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prepulse inhibition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in radial glia guided migration of Purkinje cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse structural plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone cytoplasmic component ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    catenin alpha-2
    Names
    catenin (cadherin associated protein), alpha 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106598.2 → NP_001100068.1  catenin alpha-2 isoform 1

      See identical proteins and their annotated locations for NP_001100068.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JYF7, A6IAF1
      Conserved Domains (1) summary
      pfam01044
      Location:81 → 914
      Vinculin; Vinculin family

    2. NM_001415842.1 → NP_001402771.1  catenin alpha-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Related
      ENSRNOP00000007972.8, ENSRNOT00000007971.8

    3. NM_001415843.1 → NP_001402772.1  catenin alpha-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IAF1
      Related
      ENSRNOP00000070637.2, ENSRNOT00000080999.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      110852265..112001351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285787.1 → XP_063141857.1  catenin alpha-2 isoform X2

    2. XM_017592545.3 → XP_017448034.1  catenin alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYF7, A6IAF1
      Conserved Domains (1) summary
      pfam01044
      Location:81 → 914
      Vinculin; Vinculin family
    Nucleotide Protein Strain
    Heading Accession and Version

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