Adam23 a disintegrin and metallopeptidase domain 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam23provided by MGI
Official Full Name: a disintegrin and metallopeptidase domain 23provided by MGI
Primary source: MGI:MGI:1345162
See related: Ensembl:ENSMUSG00000025964 AllianceGenome:MGI:1345162
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MDC3
Summary: This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an inactive metalloprotease and disintegrin domains. Transgenic disruption of this gene in mice results in postnatal neurological defects including tremor and ataxia resulting in death by 2 weeks of age. [provided by RefSeq, Sep 2015]
Expression: Broad expression in cerebellum adult (RPKM 24.9), cortex adult (RPKM 15.1) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C2; 1 32.31 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (63484880..63635263)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (63445717..63596111)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.
Title: Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.
ADAM23 had a strong negative effect on the surface expression of Kv1.1 channels and on Kv1.1 current amplitude
Title: ADAM23 is a negative regulator of K(v)1.1/K(v)1.4 potassium currents.
we identified ADAM23 as a negative regulator of cardiac hypertrophy through inhibiting focal adhesion kinase-protein kinase B signaling pathway, which could be a promising therapeutic target for this malady
Title: ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK - AKT Signaling.
ADAM23 expression on DCs partially governs antigen-presentation capacities to responder CD4(+) T cells. Knockdown did not alter the maturation profile of DCs but impaired cognate T cell responses, decreased antigen-specific clonal expansion, and decreased Th cytokine production. Targeting the alpha(v)beta(3) integrin receptors resulted in similar phenotypes indicating their role in the ADAM23 response.
Title: Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor.
Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs).
Title: Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.
Adam23 knockdown up-regulates P27KIP1 in P19/ADAM23 knockdown cells, one reason that P19/ADAM23 knockdown cells can differentiate into neurons without retinoic acid induction.
Title: ADAM23 knockdown promotes neuronal differentiation of P19 embryonal carcinoma cells by up-regulating P27KIP1 expression.
Data suggest that leucine-rich glioma inactivated 3 (LGI3) may be a candidate adipokine that is perturbed in obesity and suppresses adipogenesis through its receptor, ADAM23.
Title: Leucine-rich glioma inactivated 3 regulates adipogenesis through ADAM23.
Data suggest that LGI1 binding to ADAM23 is necessary to correctly pattern neuronal morphology, and altered anatomical patterning contributes to autosomal dominant partial epilepsy with auditory features.
Title: LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology.
PrP(C) is a novel molecular partner for ADAM23 in the nervous systems.
Title: Characterization of a specific interaction between ADAM23 and cellular prion protein.
Functional role of ADAM23 during lung cancer metastatic progression by negatively modulating alpha(v)beta(3) integrin activation.
Title: ADAM23 negatively modulates alpha(v)beta(3) integrin activation during metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (5) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW046396 (e-PCR)
- UniSTS:164117

44.MMHAP76FLG5.seq (e-PCR)
- UniSTS:124550

Adam23 (e-PCR), detects polymorphism
- UniSTS:141029

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IC Inferred by Curator more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 23

Names: a disintegrin and metalloprotease domain 23; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011780.3 → NP_035910.1 disintegrin and metalloproteinase domain-containing protein 23 preproprotein

See identical proteins and their annotated locations for NP_035910.1

Status: REVIEWED

Source sequence(s)

AB009673, AK046677, AL645534, AW046396

Consensus CDS

CCDS14999.1

UniProtKB/Swiss-Prot

Q6QDY9, Q6QDZ0, Q8CC33, Q9R1V7

Related

ENSMUSP00000084633.4, ENSMUST00000087374.10

Conserved Domains (5) summary

smart00608
Location:584 → 723

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:296 → 491

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:508 → 581

Disintegrin; Disintegrin

pfam01421
Location:296 → 493

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:144 → 246

Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

63484880..63635263

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495969.5 → XP_006496032.1 disintegrin and metalloproteinase domain-containing protein 23 isoform X1

UniProtKB/Swiss-Prot

Q9R1V7

Related

ENSMUSP00000109742.2, ENSMUST00000114107.3

Conserved Domains (4) summary

smart00608
Location:584 → 723

ACR; ADAM Cysteine-Rich Domain

pfam00200
Location:508 → 580

Disintegrin

pfam01421
Location:296 → 493

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:124 → 246

Pep_M12B_propep; Reprolysin family propeptide
XM_006495970.5 → XP_006496033.1 disintegrin and metalloproteinase domain-containing protein 23 isoform X2

UniProtKB/Swiss-Prot

Q9R1V7

Related

ENSMUSP00000139862.2, ENSMUST00000114103.8

Conserved Domains (4) summary

smart00608
Location:584 → 723

ACR; ADAM Cysteine-Rich Domain

pfam00200
Location:508 → 580

Disintegrin

pfam01421
Location:296 → 493

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:124 → 246

Pep_M12B_propep; Reprolysin family propeptide

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001177600.1: Suppressed sequence

Description

NM_001177600.1: This RefSeq was removed because currently there is insufficient support for the transcript.