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    Ergic2 ERGIC and golgi 2 [ Mus musculus (house mouse) ]

    Gene ID: 67456, updated on 9-May-2024

    Summary

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    Official Symbol
    Ergic2provided by MGI
    Official Full Name
    ERGIC and golgi 2provided by MGI
    Primary source
    MGI:MGI:1914706
    See related
    Ensembl:ENSMUSG00000030304 AllianceGenome:MGI:1914706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ptx1; 1200009B18Rik; 4930572C01Rik
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and membrane. Orthologous to human ERGIC2 (ERGIC and golgi 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 11.8), testis adult (RPKM 11.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ergic2 in Genome Data Viewer
    Location:
    6 G3; 6 78.49 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148080816..148113886, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148179318..148212388, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15762 Neighboring gene STARR-seq mESC enhancer starr_17826 Neighboring gene STARR-seq mESC enhancer starr_17827 Neighboring gene fatty acyl CoA reductase 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_17828 Neighboring gene fatty acyl CoA reductase 2 Neighboring gene STARR-seq mESC enhancer starr_17829 Neighboring gene STARR-seq mESC enhancer starr_17830 Neighboring gene RIKEN cDNA 4732416N19 gene Neighboring gene STARR-positive B cell enhancer ABC_E540 Neighboring gene STARR-positive B cell enhancer ABC_E3694 Neighboring gene predicted gene, 52483 Neighboring gene transmembrane and tetratricopeptide repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_17834 Neighboring gene ribosomal protein S4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Guan L, et al. Traffic, 2022 Mar. PMID 34994051
    2. Ergic2, a brain specific interacting partner of Otoferlin. Żak M, et al. Cell Physiol Biochem, 2012. PMID 22613993
    3. The human IL-3/granulocyte-macrophage colony-stimulating factor locus is epigenetically silent in immature thymocytes and is progressively activated during T cell development. Mirabella F, et al. J Immunol, 2010 Mar 15. PMID 20147630
    4. Hoxa2 plays a direct role in murine palate development. Smith TM, et al. Dev Dyn, 2009 Sep. PMID 19653318
    5. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Hrabé de Angelis MH, et al. Nat Genet, 2000 Aug. PMID 10932192

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retrograde transporter complex, Golgi to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transporter complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum-Golgi intermediate compartment protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286560.1 → NP_001273489.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC132613, AK016275, AK030045, AK162267
      UniProtKB/Swiss-Prot
      Q9CR89
      Conserved Domains (1) summary
      pfam07970
      Location:87 → 249
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    2. NM_026168.4 → NP_080444.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 1

      See identical proteins and their annotated locations for NP_080444.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC132613, AK016275, AK030045
      Consensus CDS
      CCDS20708.1
      UniProtKB/Swiss-Prot
      B2KFC8, Q3UX13, Q9CR89, Q9CWM6, Q9CYA2, Q9D4R1, Q9D8Z9
      Related
      ENSMUSP00000120456.2, ENSMUST00000136008.8
      Conserved Domains (2) summary
      pfam07970
      Location:170 → 332
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:13 → 95
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      148080816..148113886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255556.1 → XP_030111416.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X2

      Conserved Domains (2) summary
      pfam07970
      Location:170 → 322
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:13 → 95
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    2. XM_006507089.5 → XP_006507152.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006507152.1

      Conserved Domains (2) summary
      pfam07970
      Location:170 → 322
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:13 → 95
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    3. XM_030255558.2 → XP_030111418.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X6

      Conserved Domains (1) summary
      pfam07970
      Location:71 → 233
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    4. XM_030255557.2 → XP_030111417.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X4

      Conserved Domains (1) summary
      pfam07970
      Location:87 → 249
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    5. XM_030255560.2 → XP_030111420.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X7

      Conserved Domains (1) summary
      pfam07970
      Location:45 → 207
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    6. XM_030255559.2 → XP_030111419.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X6

      Conserved Domains (1) summary
      pfam07970
      Location:71 → 233
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    7. XM_030255561.2 → XP_030111421.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A0N4SVQ6
      Related
      ENSMUSP00000145204.2, ENSMUST00000203268.2
      Conserved Domains (1) summary
      pfam07970
      Location:45 → 197
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter

    8. XM_017321716.3 → XP_017177205.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2KFC8, Q3UX13, Q9CR89, Q9CWM6, Q9CYA2, Q9D4R1, Q9D8Z9
      Conserved Domains (2) summary
      pfam07970
      Location:170 → 332
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:13 → 95
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    9. XM_017321717.1 → XP_017177206.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q9CR89
      Conserved Domains (2) summary
      pfam07970
      Location:170 → 280
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:13 → 95
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    10. XM_011241623.3 → XP_011239925.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X5

      See identical proteins and their annotated locations for XP_011239925.1

      Conserved Domains (2) summary
      pfam07970
      Location:170 → 270
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:13 → 95
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    RNA

    1. XR_001785162.2 RNA Sequence

    2. XR_378169.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026355.3: Suppressed sequence

      Description
      NM_026355.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR89.1 GenPept UniProtKB/Swiss-Prot:Q9CR89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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