GSTT1 glutathione S-transferase theta 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GSTT1provided by HGNC
Official Full Name: glutathione S-transferase theta 1provided by HGNC
Primary source: HGNC:HGNC:4641
See related: MIM:600436
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Annotation information: Annotation category: only annotated on alternate loci in reference assembly
Orthologs: mouse all
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Genomic context

Location:: 22q11.23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22 (ALT_REF_LOCI_1)	NT_187633.1 (270308..278486, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (24441300..24449468, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (24376133..24384311, complement)

NT_187633.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Combined genetic polymorphisms of the GSTT1 and NRF2 genes increase susceptibility to cisplatin-induced ototoxicity: A preliminary study.
Title: Combined genetic polymorphisms of the GSTT1 and NRF2 genes increase susceptibility to cisplatin-induced ototoxicity: A preliminary study.
GSTs genetic polymorphism, gene-environment interaction and association with gallbladder cancer risk in North Indian population: A case-controlled study.
Title: GSTs genetic polymorphism, gene-environment interaction and association with gallbladder cancer risk in North Indian population: A case-controlled study.
Association of Oral Submucous Fibrosis Risk with GSTM1 and GSTT1 Gene Polymorphisms.
Title: Association of Oral Submucous Fibrosis Risk with GSTM1 and GSTT1 Gene Polymorphisms.
Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study.
Title: Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study.
Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.
Title: Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.
Association Between the XRCC1, GSTM1, and GSTT1 Polymorphisms in Model of Thyroid Cancer: A Meta-Analysis.
Title: Association Between the XRCC1, GSTM1, and GSTT1 Polymorphisms in Model of Thyroid Cancer: A Meta-Analysis.
Analysis of null deletion polymorphism of glutathione S-transferase theta (GSTT-1), associated with anti-GSTT-1 antibodies development in transplantation.
Title: Analysis of null deletion polymorphism of glutathione S-transferase theta (GSTT-1), associated with anti-GSTT-1 antibodies development in transplantation.
Progonostic effect of GSTM1/GSTT1 polymorphism in determining cardiovascular diseases risk among type 2 diabetes patients in South Indian population.
Title: Progonostic effect of GSTM1/GSTT1 polymorphism in determining cardiovascular diseases risk among type 2 diabetes patients in South Indian population.
GSTM1 and GSTT1 polymorphisms and risk of preeclampsia: a system review and meta-analysis.
Title: GSTM1 and GSTT1 polymorphisms and risk of preeclampsia: a system review and meta-analysis.
Mixed exposure effect of seminal metals on semen quality, mediation of total antioxidant capacity, and moderation of GSTM1/GSTT1 gene deletion in Chinese reproductive-aged men.
Title: Mixed exposure effect of seminal metals on semen quality, mediation of total antioxidant capacity, and moderation of GSTM1/GSTT1 gene deletion in Chinese reproductive-aged men.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

G54109 (e-PCR)
- UniSTS:109346

G66734 (e-PCR)
- UniSTS:166947

G66735 (e-PCR)
- UniSTS:166948

G66736 (e-PCR)
- UniSTS:166949

G66737 (e-PCR)
- UniSTS:166950

G66738 (e-PCR)
- UniSTS:166951

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2279 (e-PCR)
- UniSTS:473907

D11S3114 (e-PCR)
- UniSTS:152207

D16S2954 (e-PCR)
- UniSTS:42184

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: glutathione S-transferase theta-1

Names: GST class-theta-1; glutathione transferase T1-1

NP_000844.2

EC 2.5.1.18

NP_001280736.1

EC 2.5.1.18

NP_001280737.1

EC 2.5.1.18

NP_001280738.1

EC 2.5.1.18

NP_001280739.1

EC 2.5.1.18

NP_001280740.1

EC 2.5.1.18

NP_001280741.1

EC 2.5.1.18

NP_001280742.1

EC 2.5.1.18

NP_001280743.1

EC 2.5.1.18

XP_054181554.1

EC 2.5.1.18

XP_054185431.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000853.4 → NP_000844.2 glutathione S-transferase theta-1 isoform a

See identical proteins and their annotated locations for NP_000844.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AP000351

UniProtKB/Swiss-Prot

O00226, P30711, Q5TZY2, Q6IC69, Q969K8, Q96IY3

Conserved Domains (2) summary

cd03183
Location:91 → 216

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

cd03050
Location:3 → 78

GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
NM_001293807.1 → NP_001280736.1 glutathione S-transferase theta-1 isoform b

See identical proteins and their annotated locations for NP_001280736.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional exon but lacks a different exon, which results in a frameshifted segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AF435971, BG536639, CA306446, CA487832, DA900601

UniProtKB/TrEMBL

A0A0G2JRQ5

Conserved Domains (2) summary

cd03183
Location:103 → 202

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

cl00388
Location:3 → 37

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
NM_001293808.1 → NP_001280737.1 glutathione S-transferase theta-1 isoform c

See identical proteins and their annotated locations for NP_001280737.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate exon and uses an alternate splice site, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.

Source sequence(s)

AJ874719, CA306446, CA487832

UniProtKB/Swiss-Prot

P30711

UniProtKB/TrEMBL

Q4GZS9

Conserved Domains (1) summary

cl02776
Location:1 → 98

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
NM_001293809.1 → NP_001280738.1 glutathione S-transferase theta-1 isoform c

See identical proteins and their annotated locations for NP_001280738.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate exons, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.

Source sequence(s)

CA306446, CA487832, CD701199

UniProtKB/Swiss-Prot

P30711

Conserved Domains (1) summary

cl02776
Location:1 → 98

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
NM_001293810.1 → NP_001280739.1 glutathione S-transferase theta-1 isoform c

See identical proteins and their annotated locations for NP_001280739.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate exon, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.

Source sequence(s)

CA306446, CA487832, CR456499

UniProtKB/Swiss-Prot

P30711

Conserved Domains (1) summary

cl02776
Location:1 → 98

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
NM_001293811.1 → NP_001280740.1 glutathione S-transferase theta-1 isoform c

See identical proteins and their annotated locations for NP_001280740.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate exon, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.

Source sequence(s)

BF343733, CA306446, CA487832

UniProtKB/Swiss-Prot

P30711

Conserved Domains (1) summary

cl02776
Location:1 → 98

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
NM_001293812.1 → NP_001280741.1 glutathione S-transferase theta-1 isoform c

See identical proteins and their annotated locations for NP_001280741.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate splice site, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5, 6 and 7 all encode isoform c.

Source sequence(s)

BX401239, CA306446, CA487832

UniProtKB/Swiss-Prot

P30711

Conserved Domains (1) summary

cl02776
Location:1 → 98

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
NM_001293813.1 → NP_001280742.1 glutathione S-transferase theta-1 isoform d

See identical proteins and their annotated locations for NP_001280742.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks two alternate exons, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AA298437, CA306446, CA487832

UniProtKB/TrEMBL

A0A0G2JRN4

Conserved Domains (1) summary

cd03050
Location:3 → 67

GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
NM_001293814.1 → NP_001280743.1 glutathione S-transferase theta-1 isoform e

See identical proteins and their annotated locations for NP_001280743.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks three alternate exons, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AJ867758, CA306446, CA487832

UniProtKB/TrEMBL

A0A0G2JQM5, Q4W251

Conserved Domains (1) summary

cl00388
Location:3 → 37

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold