hbba2 hemoglobin, beta adult 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hbba2provided by ZNC
Official Full Name: hemoglobin, beta adult 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-164
See related: Ensembl:ENSDARG00000069734 AllianceGenome:ZFIN:ZDB-GENE-040801-164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj42e02; zgc:92880; wu:fj42e02; zgc:113872; si:ch211-5k11.13; si:xx-by187g17.6
Summary: Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in female organism and vasculature. Human ortholog(s) of this gene implicated in acute chest syndrome; hemolytic anemia (multiple); malaria; polycythemia (multiple); and sickle cell anemia. Orthologous to several human genes including HBE1 (hemoglobin subunit epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (55091228..55092046, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (54836626..54837449, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to haptoglobin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables organic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info
contributes_to peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oxygen transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of haptoglobin-hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hemoglobin, beta adult 2; uncharacterized protein LOC445037

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003431.2 → NP_001003431.2 hemoglobin, beta adult 2

Status: VALIDATED

Source sequence(s)

AL935210

UniProtKB/TrEMBL

A0A8M2BBK3, Q6ZM12

Conserved Domains (1) summary

cd08925
Location:8 → 146

Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

55091228..55092046 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164337.4 → XP_005164394.1 uncharacterized protein LOC445037

UniProtKB/TrEMBL

Q6ZM12

Related

ENSDARP00000053076.4, ENSDART00000053077.6

Conserved Domains (1) summary

cd08925
Location:8 → 146

Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits