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    Trappc11 trafficking protein particle complex subunit 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290746, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Trappc11provided by RGD
    Official Full Name
    trafficking protein particle complex subunit 11provided by RGD
    Primary source
    RGD:1309765
    See related
    Ensembl:ENSRNOG00000022482 AllianceGenome:RGD:1309765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309765
    Summary
    Predicted to be involved in several processes, including constitutive secretory pathway; endoplasmic reticulum to Golgi vesicle-mediated transport; and regulation of protein complex stability. Predicted to be located in Golgi apparatus. Predicted to be part of TRAPP complex. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2S. Orthologous to human TRAPPC11 (trafficking protein particle complex subunit 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 157.5), Kidney (RPKM 154.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16q11
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (51465631..51512003)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (44733169..44779324)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (47874993..47920822)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ERH, mRNA splicing and mitosis factor, pseudogene 2 Neighboring gene uncharacterized LOC134482503 Neighboring gene RWD domain containing 4 Neighboring gene uncharacterized LOC134482545 Neighboring gene uncharacterized LOC102551690 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in TRAPPC11 are associated with a congenital disorder of glycosylation. Matalonga L, et al. Hum Mutat, 2017 Feb. PMID 27862579
    2. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. Scrivens PJ, et al. Mol Biol Cell, 2011 Jun 15. PMID 21525244, Free PMC Article
    3. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in constitutive secretory pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein complex stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 11
    Names
    trafficking protein particle complex 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169115.1 → NP_001162586.1  trafficking protein particle complex subunit 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6JPL4, D3ZHI8
      Related
      ENSRNOP00000018969.5, ENSRNOT00000018969.8
      Conserved Domains (2) summary
      pfam11817
      Location:263 → 522
      Foie-gras_1; Foie gras liver health family 1
      pfam12742
      Location:1036 → 1095
      Gryzun-like; Gryzun, putative Golgi trafficking

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      51465631..51512003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253134.4 → XP_006253196.1  trafficking protein particle complex subunit 11 isoform X1

      See identical proteins and their annotated locations for XP_006253196.1

      UniProtKB/TrEMBL
      A0A0G2K1K5, A6JPL4
      Related
      ENSRNOP00000071879.1
      Conserved Domains (2) summary
      pfam11817
      Location:263 → 522
      Foie-gras_1; Foie gras liver health family 1
      pfam12742
      Location:1036 → 1095
      Gryzun-like; Gryzun, putative Golgi trafficking

    2. XM_063275230.1 → XP_063131300.1  trafficking protein particle complex subunit 11 isoform X2

      UniProtKB/TrEMBL
      D3ZHI8

    3. XM_063275232.1 → XP_063131302.1  trafficking protein particle complex subunit 11 isoform X3

    4. XM_006253135.4 → XP_006253197.1  trafficking protein particle complex subunit 11 isoform X1

      See identical proteins and their annotated locations for XP_006253197.1

      UniProtKB/TrEMBL
      A0A0G2K1K5, A6JPL4
      Conserved Domains (2) summary
      pfam11817
      Location:263 → 522
      Foie-gras_1; Foie gras liver health family 1
      pfam12742
      Location:1036 → 1095
      Gryzun-like; Gryzun, putative Golgi trafficking

    5. XM_063275231.1 → XP_063131301.1  trafficking protein particle complex subunit 11 isoform X2

      UniProtKB/TrEMBL
      D3ZHI8
    Nucleotide Protein Strain
    Heading Accession and Version

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