Fgl2 fibrinogen-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgl2provided by RGD
Official Full Name: fibrinogen-like 2provided by RGD
Primary source: RGD:620170
See related: Ensembl:ENSRNOG00000012881 AllianceGenome:RGD:620170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in parturition. Predicted to act upstream of or within several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; negative regulation of antigen processing and presentation; and negative regulation of memory T cell differentiation. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human FGL2 (fibrinogen like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 372.1), Lung (RPKM 331.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (14602762..14608405, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (13710566..13716207, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (10323598..10329241, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of fibrinogen-like protein 2 (Fgl2) on Toll-like receptor 9 (TLR9) expression in autoimmune myelitis.
Title: Expression of fibrinogen-like protein 2 (Fgl2) on Toll-like receptor 9 (TLR9) expression in autoimmune myelitis.
this study shows that FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats
Title: FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats.
FGL2 plays an important role in the pathogenesis of autoimmune myocarditis that also involves the PD-1/PD-L1 pathway. Our findings may provide novel therapeutic targets for the treatment of immune-induced heart injury.
Title: Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines.
Fgl2 role in cardiomyocytes apoptosis and heart function in diabetic rats
Title: Fibrinogen-like protein 2 gene silencing inhibits cardiomyocytes apoptosis, improves heart function of streptozotocin-induced diabetes rats and the molecular mechanism involved.
STS is able to ameliorate CNR through inhibition of FGL2 expression mediated by Akt and NF-kappaB pathways as well as prevention of MVO by suppressing fibrin deposition and inflammation.
Title: Sodium tanshinone IIA sulfonate ameliorates experimental coronary no-reflow phenomenon through down-regulation of FGL2.
TNF-alpha-induced flg2 in CMECs mediates the formation of fibrin-rich microthrombus, which may be one of the mechanisms of microvascular dysfunction or obstruction due to MI/R injury.
Title: TNF-α upregulates Fgl2 expression in rat myocardial ischemia/reperfusion injury.
Microthrombosis due to fgl2 overexpression contributes to pancreatic impairment in rats with severe acute pancreatitis, and fgl2 level may serve as a biomarker during early stages of disease.
Title: Correlation of fibrinogen-like protein 2 with progression of acute pancreatitis in rats.
microthrombosis is involved in cardiac microvascular dysfunction or disturbance of rats with acute MI/R as one cause, and fgl2 may emerge as a predictor of the occurrence of no-reflow phenomenon.
Title: The significance of microthrombosis and fgl2 in no-reflow phenomenon of rats with acute myocardial ischemia/reperfusion.
In rats with type 2 diabetes, microthrombosis due to fgl2 contributes to the impairment of cardiac diastolic or systolic function and morphological changes.
Title: Expression and significance of fgl2 prothrombinase in cardiac microvascular endothelial cells of rats with type 2 diabetes.
Fgl2 prothrombinase is involved in severe acute pancreatitis-associated liver injury.
Title: Fgl2 prothrombinase is involved in severe acute pancreatitis-associated liver injury.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH141508 (e-PCR)
- UniSTS:223502

AA955206 (e-PCR)
- UniSTS:246620

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase activator activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of dendritic cell antigen processing and presentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macrophage antigen processing and presentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of memory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in parturition	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroleukin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053455.2 → NP_445907.2 fibroleukin precursor

See identical proteins and their annotated locations for NP_445907.2

Status: VALIDATED

Source sequence(s)

BC072502, CB582252

UniProtKB/TrEMBL

A6K5C1, G3V7P2, Q32Q89

Related

ENSRNOP00000017232.4, ENSRNOT00000017232.6

Conserved Domains (2) summary

pfam00147
Location:199 → 425

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

cl21509
Location:71 → 177

ApoLp-III_like; Apolipophorin-III and similar insect proteins