Isoc1 isochorismatase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Isoc1provided by RGD
Full Name: isochorismatase domain containing 1provided by RGD
Primary source: RGD:1307632
See related: Ensembl:ENSRNOG00000019711 AllianceGenome:RGD:1307632
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DR-NR#1; RGD1307632
Summary: Located in peroxisome. Orthologous to human ISOC1 (isochorismatase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 356.6), Kidney (RPKM 318.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (54356757..54377170)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (52158790..52179206)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (53727203..53747612)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134325 (e-PCR)
- UniSTS:217607

RH132613 (e-PCR)
- UniSTS:215896

Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: isochorismatase domain-containing protein 1

Names: DR-NR1; Down-regulated in nephrectomized rat kidney #1; down-regulated in nephrectomized rat kidney protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014242.2 → NP_001014264.2 isochorismatase domain-containing protein 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q6I7R3

UniProtKB/TrEMBL

F2Z3T7

Related

ENSRNOP00000026706.4, ENSRNOT00000026706.6

Conserved Domains (1) summary

cd01012
Location:115 → 269

YcaC_related; YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. ...