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    Sdhaf2 succinate dehydrogenase complex assembly factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361726, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sdhaf2provided by RGD
    Official Full Name
    succinate dehydrogenase complex assembly factor 2provided by RGD
    Primary source
    RGD:1309216
    See related
    Ensembl:ENSRNOG00000020646 AllianceGenome:RGD:1309216
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309216
    Summary
    Predicted to be involved in aerobic respiration; mitochondrial respiratory chain complex II assembly; and protein-FAD linkage. Predicted to act upstream of or within negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein dephosphorylation. Predicted to be located in cytosol and nucleolus. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SDHAF2 (succinate dehydrogenase complex assembly factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 258.3), Muscle (RPKM 236.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sdhaf2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216564002..216592877, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207139070..207167830, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226543671..226572414, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483971 Neighboring gene stabilizer of axonemal microtubules 4 Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene 5S ribosomal RNA Neighboring gene transmembrane protein 216

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-κB signaling pathway. Wu H, et al. Immunopharmacol Immunotoxicol, 2023 Jun. PMID 36326104
    2. Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase kinase 3β-β-catenin-mediated lung cancer metastasis. Liu J, et al. J Biol Chem, 2013 Oct 11. PMID 23983127, Free PMC Article
    3. SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Hao HX, et al. Science, 2009 Aug 28. PMID 19628817, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-kappaB signaling pathway.
      Title: SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-κB signaling pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105864

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial electron transport, succinate to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, succinate to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, succinate to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial electron transport, succinate to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial respiratory chain complex II assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-FAD linkage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    succinate dehydrogenase assembly factor 2, mitochondrial
    Names
    SDH assembly factor 2
    succinate dehydrogenase subunit 5, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008371.1 → NP_001008372.1  succinate dehydrogenase assembly factor 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001008372.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086542
      UniProtKB/Swiss-Prot
      Q5RJQ7
      UniProtKB/TrEMBL
      A0A8I6AIT7, A6I035
      Conserved Domains (1) summary
      pfam03937
      Location:65 → 138
      Sdh5; Flavinator of succinate dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      216564002..216592877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589442.3 → XP_017444931.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL70
      Conserved Domains (1) summary
      pfam03937
      Location:65 → 122
      Sdh5; Flavinator of succinate dehydrogenase

    2. XM_039084172.2 → XP_038940100.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZL70
      Related
      ENSRNOP00000093612.1
      Conserved Domains (1) summary
      pfam03937
      Location:65 → 122
      Sdh5; Flavinator of succinate dehydrogenase

    3. XM_063268386.1 → XP_063124456.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X6

    4. XM_006231042.3 → XP_006231104.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIT7
      Related
      ENSRNOP00000094094.1
      Conserved Domains (1) summary
      pfam03937
      Location:55 → 128
      Sdh5; Flavinator of succinate dehydrogenase

    5. XM_063268380.1 → XP_063124450.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X5

    6. XM_063268376.1 → XP_063124446.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X3

    7. XM_063268367.1 → XP_063124437.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X1

    RNA

    1. XR_010055124.1 RNA Sequence

    2. XR_010055123.1 RNA Sequence

    3. XR_010055127.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJQ7.1 GenPept UniProtKB/Swiss-Prot:Q5RJQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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