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    Gas2 growth arrest-specific 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499156, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Gas2provided by RGD
    Official Full Name
    growth arrest-specific 2provided by RGD
    Primary source
    RGD:1563167
    See related
    Ensembl:ENSRNOG00000016717 AllianceGenome:RGD:1563167
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563167
    Summary
    Predicted to enable actin filament binding activity and cytoskeletal anchor activity. Predicted to be involved in actin crosslink formation. Predicted to act upstream of or within several processes, including ovarian follicle development; ovulation; and regulation of Notch signaling pathway. Predicted to be active in actin filament. Orthologous to human GAS2 (growth arrest specific 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 207.5), Adrenal (RPKM 34.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gas2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (110587952..110721572)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (101452361..101582619)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (107234389..107363624)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099815 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene FA complementation group F Neighboring gene small VCP interacting protein Neighboring gene coiled-coil domain containing 179

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Growth Arrest Specific 2 (GAS2) is a Critical Mediator of Germ Cell Cyst Breakdown and Folliculogenesis in Mice. York JP, et al. Sci Rep, 2016 Oct 13. PMID 27734842, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal anchor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antral ovarian follicle growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within basement membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within initiation of primordial ovarian follicle growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    growth arrest-specific protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127504.1 → NP_001120976.1  growth arrest-specific protein 2

      See identical proteins and their annotated locations for NP_001120976.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JBH5, A6JBH6, G3V857
      Related
      ENSRNOP00000022499.5, ENSRNOT00000022499.7
      Conserved Domains (2) summary
      smart00243
      Location:201 → 274
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cd00014
      Location:36 → 158
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      110587952..110721572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589558.3 → XP_017445047.1  growth arrest-specific protein 2 isoform X1

      Conserved Domains (2) summary
      cd00014
      Location:36 → 158
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl02524
      Location:201 → 292
      GAS2; Growth-Arrest-Specific Protein 2 Domain

    2. XM_063271101.1 → XP_063127171.1  growth arrest-specific protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JBH5, G3V857

    3. XM_063271078.1 → XP_063127148.1  growth arrest-specific protein 2 isoform X1

    4. XM_039087544.2 → XP_038943472.1  growth arrest-specific protein 2 isoform X3

      Conserved Domains (1) summary
      cl00030
      Location:30 → 158
      CH_SF; calponin homology (CH) domain superfamily

    5. XM_017589559.3 → XP_017445048.1  growth arrest-specific protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JBH5, A6JBH6, G3V857
      Conserved Domains (2) summary
      smart00243
      Location:201 → 274
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cd00014
      Location:36 → 158
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    6. XM_063271093.1 → XP_063127163.1  growth arrest-specific protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JBH5, G3V857

    7. XM_063271070.1 → XP_063127140.1  growth arrest-specific protein 2 isoform X1

    8. XM_063271086.1 → XP_063127156.1  growth arrest-specific protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JBH5, G3V857

    9. XM_063271105.1 → XP_063127175.1  growth arrest-specific protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JBH5, G3V857

    10. XM_063271079.1 → XP_063127149.1  growth arrest-specific protein 2 isoform X1

    11. XM_063271067.1 → XP_063127137.1  growth arrest-specific protein 2 isoform X1

    12. XM_063271089.1 → XP_063127159.1  growth arrest-specific protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JBH5, G3V857

    13. XM_006229273.5 → XP_006229335.1  growth arrest-specific protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006229335.1

      Conserved Domains (2) summary
      cd00014
      Location:36 → 158
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl02524
      Location:201 → 292
      GAS2; Growth-Arrest-Specific Protein 2 Domain
    Nucleotide Protein Strain
    Heading Accession and Version

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