Ripor1 RHO family interacting cell polarization regulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ripor1provided by RGD
Official Full Name: RHO family interacting cell polarization regulator 1provided by RGD
Primary source: RGD:1307772
See related: Ensembl:ENSRNOG00000017604 AllianceGenome:RGD:1307772
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam65a; RGD1307772
Summary: Predicted to enable 14-3-3 protein binding activity. Predicted to be involved in several processes, including establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange factor activity; and negative regulation of Rho protein signal transduction. Predicted to be located in Golgi apparatus; cell leading edge; and membrane. Predicted to be active in cytoplasm. Orthologous to human RIPOR1 (RHO family interacting cell polarization regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 148.7), Lung (RPKM 86.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50387447..50416323)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (33477750..33506424)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (37555940..37584842)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW520830 (e-PCR)
- UniSTS:249354

BE107893 (e-PCR)
- UniSTS:247109

RH132883 (e-PCR)
- UniSTS:216166

BF390465 (e-PCR)
- UniSTS:249478

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables 14-3-3 protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of Golgi localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of Golgi localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to Golgi apparatus	IEA Inferred from Electronic Annotation more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rho family-interacting cell polarization regulator 1

Names: family with sequence similarity 65, member A; protein FAM65A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100660.1 → NP_001094130.1 rho family-interacting cell polarization regulator 1

See identical proteins and their annotated locations for NP_001094130.1

Status: VALIDATED

Source sequence(s)

AY724537, BF524907, FQ147070

UniProtKB/Swiss-Prot

Q4FZU8

UniProtKB/TrEMBL

A0A0G2JVR9, A6IYQ8

Related

ENSRNOP00000023710.5, ENSRNOT00000023710.7

Conserved Domains (4) summary

pfam05109
Location:497 → 747

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00044
Location:1091 → 1121

HEAT; HEAT repeat [structural motif]

pfam13646
Location:1119 → 1183

HEAT_2; HEAT repeats

pfam15903
Location:17 → 365

PL48; Filopodia upregulated, FAM65

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

50387447..50416323

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277922.1 → XP_063133992.1 rho family-interacting cell polarization regulator 1 isoform X3

UniProtKB/TrEMBL

A6IYQ6
XM_063277924.1 → XP_063133994.1 rho family-interacting cell polarization regulator 1 isoform X5
XM_063277921.1 → XP_063133991.1 rho family-interacting cell polarization regulator 1 isoform X1
XM_063277923.1 → XP_063133993.1 rho family-interacting cell polarization regulator 1 isoform X4
XM_006255474.5 → XP_006255536.1 rho family-interacting cell polarization regulator 1 isoform X2

UniProtKB/TrEMBL

A0A0G2JVR9, A0A8I6B430

Related

ENSRNOP00000096363.1

Conserved Domains (3) summary

pfam13646
Location:1134 → 1197

HEAT_2; HEAT repeats

pfam15903
Location:31 → 379

PL48; Filopodia upregulated, FAM65

sd00044
Location:1105 → 1135

HEAT; HEAT repeat [structural motif]