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    Zfp24 zinc finger protein 24 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360204, updated on 29-Feb-2024

    Summary

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    Official Symbol
    Zfp24provided by RGD
    Official Full Name
    zinc finger protein 24provided by RGD
    Primary source
    RGD:727963
    See related
    Ensembl:ENSRNOG00000016562 AllianceGenome:RGD:727963
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf24; Zfp191
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in myelination; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Orthologous to human ZNF24 (zinc finger protein 24). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 78.0), Heart (RPKM 77.8) and 9 other tissues See more
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    Genomic context

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    See Zfp24 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (15573031..15583432, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (15295687..15307319, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (15910175..15921757, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 35 Neighboring gene proline-rich nuclear receptor coactivator 1. pseudogene 1 Neighboring gene INO80 complex subunit C Neighboring gene polypeptide N-acetylgalactosaminyltransferase 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191. Wang H, et al. Acta Biochim Biophys Sin (Shanghai), 2008 Aug. PMID 18685786
    2. Quantitative effects on gene silencing by allelic variation at a tetranucleotide microsatellite. Albanèse V, et al. Hum Mol Genet, 2001 Aug 15. PMID 11532988
    3. ZFP191 is required by oligodendrocytes for CNS myelination. Howng SY, et al. Genes Dev, 2010 Feb 1. PMID 20080941, Free PMC Article
    4. Identification and characterization of two novel human SCAN domain-containing zinc finger genes ZNF396 and ZNF397. Wu Y, et al. Gene, 2003 May 22. PMID 12801647
    5. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. Han ZG, et al. J Biol Chem, 1999 Dec 10. PMID 10585455

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 24
    Names
    zfp-191
    zinc finger protein 191

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182955.1 → NP_892000.1  zinc finger protein 24

      See identical proteins and their annotated locations for NP_892000.1

      Status: PROVISIONAL

      Source sequence(s)
      AY336973
      UniProtKB/Swiss-Prot
      Q7TNK3
      UniProtKB/TrEMBL
      A6J2J7
      Conserved Domains (7) summary
      smart00431
      Location:48 → 159
      SCAN; leucine rich region
      COG5048
      Location:305 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:48 → 136
      SCAN; SCAN domain
      pfam13465
      Location:294 → 318
      zf-H2C2_2; Zinc-finger double domain
      cl11685
      Location:101 → 173
      CdhC; CO dehydrogenase/acetyl-CoA synthase complex beta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      15573031..15583432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254464.5 → XP_006254526.1  zinc finger protein 24 isoform X1

      See identical proteins and their annotated locations for XP_006254526.1

      UniProtKB/Swiss-Prot
      Q7TNK3
      UniProtKB/TrEMBL
      A6J2J7
      Conserved Domains (7) summary
      smart00431
      Location:48 → 159
      SCAN; leucine rich region
      COG5048
      Location:305 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:48 → 136
      SCAN; SCAN domain
      pfam13465
      Location:294 → 318
      zf-H2C2_2; Zinc-finger double domain
      cl11685
      Location:101 → 173
      CdhC; CO dehydrogenase/acetyl-CoA synthase complex beta subunit

    2. XM_006254465.5 → XP_006254527.1  zinc finger protein 24 isoform X1

      See identical proteins and their annotated locations for XP_006254527.1

      UniProtKB/Swiss-Prot
      Q7TNK3
      UniProtKB/TrEMBL
      A6J2J7
      Related
      ENSRNOP00000022304.2
      Conserved Domains (7) summary
      smart00431
      Location:48 → 159
      SCAN; leucine rich region
      COG5048
      Location:305 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:48 → 136
      SCAN; SCAN domain
      pfam13465
      Location:294 → 318
      zf-H2C2_2; Zinc-finger double domain
      cl11685
      Location:101 → 173
      CdhC; CO dehydrogenase/acetyl-CoA synthase complex beta subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNK3.1 GenPept UniProtKB/Swiss-Prot:Q7TNK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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