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    Hddc2 HD domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361462, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hddc2provided by RGD
    Official Full Name
    HD domain containing 2provided by RGD
    Primary source
    RGD:1307562
    See related
    Ensembl:ENSRNOG00000021442 AllianceGenome:RGD:1307562
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307562
    Summary
    Predicted to enable 5'-deoxynucleotidase activity. Predicted to be involved in dephosphorylation. Orthologous to human HDDC2 (HD domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 79.2), Muscle (RPKM 63.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hddc2 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (28100669..28133008, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (26294030..26313914, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (28567447..28600116, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 217 Neighboring gene uncharacterized LOC134484976 Neighboring gene TPD52 like 1 Neighboring gene uncharacterized LOC134484854 Neighboring gene SEC24 homolog C, COPII coat complex component, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-deoxynucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5'-deoxynucleotidase HDDC2
    Names
    HD domain-containing protein 2
    NP_001101930.1
    XP_038937096.1
    XP_063122124.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108460.1 → NP_001101930.1  5'-deoxynucleotidase HDDC2

      See identical proteins and their annotated locations for NP_001101930.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474002
      UniProtKB/TrEMBL
      A6JUR8, D3ZKT8
      Related
      ENSRNOP00000034339.4, ENSRNOT00000029444.7
      Conserved Domains (1) summary
      pfam13023
      Location:19 → 175
      HD_3; HD domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      28100669..28133008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266054.1 → XP_063122124.1  5'-deoxynucleotidase HDDC2 isoform X1

    2. XM_039081168.2 → XP_038937096.1  5'-deoxynucleotidase HDDC2 isoform X2

      Conserved Domains (1) summary
      pfam13023
      Location:1 → 131
      HD_3; HD domain
    Nucleotide Protein Strain
    Heading Accession and Version

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