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    Ackr4 atypical chemokine receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685243, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ackr4provided by RGD
    Official Full Name
    atypical chemokine receptor 4provided by RGD
    Primary source
    RGD:1596453
    See related
    Ensembl:ENSRNOG00000011478 AllianceGenome:RGD:1596453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccrl1
    Summary
    Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human ACKR4 (atypical chemokine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 46.3), Lung (RPKM 32.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ackr4 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (113595325..113599762, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (104716537..104720972, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (112643838..112651668, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene nephrocystin 3 Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene acyl-CoA dehydrogenase family, member 11 Neighboring gene uncharacterized LOC120094252 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene uncharacterized LOC134480097

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. Watts AO, et al. J Biol Chem, 2013 Mar 8. PMID 23341447, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    atypical chemokine receptor 4
    Names
    C-C chemokine receptor type 11
    chemokine (C-C motif) receptor-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399385.2 → NP_001386314.1  atypical chemokine receptor 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I2L5, G3V9V6
      Related
      ENSRNOP00000061118.3, ENSRNOT00000015265.6
      Conserved Domains (2) summary
      cd14964
      Location:42 → 69
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:42 → 314
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      113595325..113599762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266147.1 → XP_063122217.1  atypical chemokine receptor 4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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