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    Dlgap1 DLG associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65040, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Dlgap1provided by RGD
    Official Full Name
    DLG associated protein 1provided by RGD
    Primary source
    RGD:620223
    See related
    Ensembl:ENSRNOG00000016196 AllianceGenome:RGD:620223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gkap; DAP-1; rGKAP; SAPAP1; GKAP/SAPAP1
    Summary
    Enables protein domain specific binding activity. A structural constituent of postsynaptic density. Involved in aggresome assembly; protein localization to synapse; and regulation of proteasomal protein catabolic process. Located in postsynaptic density and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human DLGAP1 (DLG associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 171.0), Lung (RPKM 19.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q38
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (117304144..118173463)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (109857500..110726817)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (118277046..119159807)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480431 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene A-kinase anchor inhibitor 1 Neighboring gene uncharacterized LOC134480625 Neighboring gene dephospho-CoA kinase domain-containing protein-like Neighboring gene uncharacterized LOC120094814 Neighboring gene uncharacterized LOC102555426 Neighboring gene uncharacterized LOC134480624 Neighboring gene uncharacterized LOC102555570 Neighboring gene uncharacterized LOC120094777 Neighboring gene TGFB-induced factor homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray crystallographic analysis of the C-terminal domain of guanylate kinase-associated protein from Rattus norvegicus. Tong J, et al. Acta Crystallogr F Struct Biol Commun, 2014 Jul. PMID 25005096, Free PMC Article
    2. GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling. Shin SM, et al. Nat Neurosci, 2012 Dec. PMID 23143515, Free PMC Article
    3. Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons. Hung AY, et al. PLoS One, 2010 Mar 24. PMID 20352094, Free PMC Article
    4. Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein. Yao I, et al. J Biol Chem, 1999 Sep 24. PMID 10488079
    5. Differential expression of isoforms of PSD-95 binding protein (GKAP/SAPAP1) during rat brain development. Kawashima N, et al. FEBS Lett, 1997 Dec 1. PMID 9428732

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upon depolarization with high K+, neither the intensity nor distribution of label for GKAP changed, but labeling intensity for Shank at the postsynaptic density increased to ~150% of controls.
      Title: Differential distribution of Shank and GKAP at the postsynaptic density.
    2. The C-terminal helical domain of GKAP from Rattus norvegicus was purified and crystallized as a fusion protein.
      Title: Crystallization and preliminary X-ray crystallographic analysis of the C-terminal domain of guanylate kinase-associated protein from Rattus norvegicus.
    3. Phosphorylated serine residues in several of the identified phosphorylation sites were followed by prolines, suggesting prominent involvement of proline directed kinases in the regulation of PSD components.
      Title: Identification of novel phosphorylation sites on postsynaptic density proteins.
    4. Activity-dependent turnover of postsynnaptic density proteins orchestrated by GKAP is critical for homeostatic plasticity.
      Title: GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling.
    5. postsynaptic scaffold GKAP is degraded and dendritic spine morphology is regulated by the TRIM3 ubiquitin ligase in rat hippocampal neurons
      Title: Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of postsynaptic density IC
    Inferred by Curator
    more info
    		  
    enables structural constituent of postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aggresome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of postsynaptic density structure IC
    Inferred by Curator
    more info
    		  
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    disks large-associated protein 1
    Names
    PSD-95 binding protein
    PSD-95/SAP90-binding protein 1
    SAP90/PSD-95-associated protein 1
    discs large homolog associated protein 1
    guanylate kinase-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304287.1 → NP_001291216.1  disks large-associated protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three 5' exons, contains an alternate 5' terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AE66
      Related
      ENSRNOP00000072852.1, ENSRNOT00000087592.2
      Conserved Domains (1) summary
      pfam03359
      Location:360 → 692
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. NM_022946.3 → NP_075235.3  disks large-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_075235.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
      Related
      ENSRNOP00000073938.1, ENSRNOT00000090512.2
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      117304144..118173463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084190.2 → XP_038940118.1  disks large-associated protein 1 isoform X3

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      Conserved Domains (1) summary
      pfam03359
      Location:632 → 964
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. XM_039084191.2 → XP_038940119.1  disks large-associated protein 1 isoform X4

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A6KF82
      Conserved Domains (1) summary
      pfam03359
      Location:622 → 954
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    3. XM_039084189.2 → XP_038940117.1  disks large-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    4. XM_039084188.2 → XP_038940116.1  disks large-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    5. XM_017596627.3 → XP_017452116.1  disks large-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    6. XM_017596630.3 → XP_017452119.1  disks large-associated protein 1 isoform X2

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      G3V849
      Related
      ENSRNOP00000022351.8

    7. XM_063267696.1 → XP_063123766.1  disks large-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81

    8. XM_017596628.3 → XP_017452117.1  disks large-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    9. XM_063267703.1 → XP_063123773.1  disks large-associated protein 1 isoform X17

    10. XM_063267701.1 → XP_063123771.1  disks large-associated protein 1 isoform X15

    11. XM_039084192.2 → XP_038940120.1  disks large-associated protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZYB2
      Related
      ENSRNOP00000084169.1
      Conserved Domains (1) summary
      pfam03359
      Location:341 → 673
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    12. XM_063267697.1 → XP_063123767.1  disks large-associated protein 1 isoform X6

    13. XM_008767429.4 → XP_008765651.1  disks large-associated protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZYB2
      Conserved Domains (1) summary
      pfam03359
      Location:379 → 711
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    14. XM_063267704.1 → XP_063123774.1  disks large-associated protein 1 isoform X18

    15. XM_063267700.1 → XP_063123770.1  disks large-associated protein 1 isoform X13

    16. XM_063267702.1 → XP_063123772.1  disks large-associated protein 1 isoform X16

    17. XM_039084193.2 → XP_038940121.1  disks large-associated protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZYB2, A6KF84
      Conserved Domains (1) summary
      pfam03359
      Location:334 → 666
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    18. XM_063267699.1 → XP_063123769.1  disks large-associated protein 1 isoform X9

    19. XM_008767430.4 → XP_008765652.1  disks large-associated protein 1 isoform X7

      See identical proteins and their annotated locations for XP_008765652.1

      UniProtKB/TrEMBL
      A0A8I6AE66, A6KF83
      Conserved Domains (1) summary
      pfam03359
      Location:362 → 694
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    20. XM_017596631.3 → XP_017452120.1  disks large-associated protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AE66

    21. XM_008767432.4 → XP_008765654.1  disks large-associated protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AE66
      Related
      ENSRNOP00000090776.1
      Conserved Domains (1) summary
      pfam03359
      Location:352 → 684
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    22. XM_008767433.4 → XP_008765655.1  disks large-associated protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8I6AE66
      Conserved Domains (1) summary
      pfam03359
      Location:341 → 673
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97836.1 GenPept UniProtKB/Swiss-Prot:P97836

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