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    Cept1 choline/ethanolamine phosphotransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310773, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cept1provided by RGD
    Official Full Name
    choline/ethanolamine phosphotransferase 1provided by RGD
    Primary source
    RGD:1359727
    See related
    Ensembl:ENSRNOG00000017723 AllianceGenome:RGD:1359727
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable diacylglycerol cholinephosphotransferase activity and ethanolaminephosphotransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to act upstream of or within phosphatidylcholine biosynthetic process. Predicted to be located in nuclear membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. Orthologous to human CEPT1 (choline/ethanolamine phosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 250.3), Spleen (RPKM 139.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (196682455..196724430, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (193994220..194036141, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (209118140..209162071, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 9 Neighboring gene uncharacterized LOC100912312 Neighboring gene DENN domain containing 2D Neighboring gene DNA damage regulated autophagy modulator 2 Neighboring gene uncharacterized LOC134485947 Neighboring gene uncharacterized LOC120100909 Neighboring gene ligand dependent nuclear receptor interacting factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1). Wright MM, et al. Lipids, 2002 Jul. PMID 12216837
    2. Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine. Henneberry AL, et al. Biochem J, 1999 Apr 15. PMID 10191259, Free PMC Article
    3. Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination. Butler PL, et al. J Biol Chem, 2010 Feb 26. PMID 20018880, Free PMC Article
    4. Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. Kulinski A, et al. J Biol Chem, 2002 Aug 30. PMID 12072432
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC95031

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-alkenyl-2-acylglycerol choline phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolaminephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    choline/ethanolaminephosphotransferase 1
    Names
    1-alkenyl-2-acylglycerol choline phosphotransferase
    NP_001007700.1
    XP_006233178.1
    XP_006233179.1
    XP_006233180.1
    XP_017446413.1
    XP_038958347.1
    XP_063137986.1
    XP_063137987.1
    XP_063137988.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007699.1 → NP_001007700.1  choline/ethanolaminephosphotransferase 1

      See identical proteins and their annotated locations for NP_001007700.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079471
      UniProtKB/Swiss-Prot
      Q6AXM5
      UniProtKB/TrEMBL
      A6HUQ5
      Conserved Domains (1) summary
      cl00453
      Location:43 → 411
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      196682455..196724430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233118.5 → XP_006233180.1  choline/ethanolaminephosphotransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_006233180.1

      UniProtKB/Swiss-Prot
      Q6AXM5
      UniProtKB/TrEMBL
      A6HUQ5
      Conserved Domains (1) summary
      cl00453
      Location:43 → 411
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    2. XM_063281918.1 → XP_063137988.1  choline/ethanolaminephosphotransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMF2, A6HUQ6

    3. XM_006233116.4 → XP_006233178.1  choline/ethanolaminephosphotransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_006233178.1

      UniProtKB/Swiss-Prot
      Q6AXM5
      UniProtKB/TrEMBL
      A6HUQ5
      Related
      ENSRNOP00000032597.3, ENSRNOT00000036551.5
      Conserved Domains (1) summary
      cl00453
      Location:43 → 411
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    4. XM_006233117.5 → XP_006233179.1  choline/ethanolaminephosphotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006233179.1

      UniProtKB/TrEMBL
      A0A8I5ZMF2, A6HUQ6
      Related
      ENSRNOP00000079153.1
      Conserved Domains (1) summary
      cl00453
      Location:43 → 411
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    5. XM_063281916.1 → XP_063137986.1  choline/ethanolaminephosphotransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMF2, A6HUQ6

    6. XM_017590924.3 → XP_017446413.1  choline/ethanolaminephosphotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q6AXM5
      UniProtKB/TrEMBL
      A6HUQ5
      Conserved Domains (1) summary
      cl00453
      Location:43 → 411
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    7. XM_063281917.1 → XP_063137987.1  choline/ethanolaminephosphotransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMF2, A6HUQ6

    8. XM_039102419.2 → XP_038958347.1  choline/ethanolaminephosphotransferase 1 isoform X3

      Conserved Domains (1) summary
      cl00453
      Location:43 → 209
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXM5.1 GenPept UniProtKB/Swiss-Prot:Q6AXM5

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