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    Mllt1 MLLT1, super elongation complex subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301119, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Mllt1provided by RGD
    Official Full Name
    MLLT1, super elongation complex subunitprovided by RGD
    Primary source
    RGD:1588581
    See related
    Ensembl:ENSRNOG00000048736 AllianceGenome:RGD:1588581
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of protein kinase activity. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of transcription elongation factor complex. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 76.2), Lung (RPKM 73.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mllt1 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1818204..1863091, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1731077..1775985, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10110389..10155305)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase bubblegum family member 2 Neighboring gene acyl-CoA synthetase bubblegum family member 3 Neighboring gene U7 small nuclear RNA Neighboring gene BCL2 interacting protein 3, pseudogene 5 Neighboring gene alkaline ceramidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk. Kikuchi Y, et al. Int Immunol, 2000 Oct. PMID 11007757
    2. The super elongation complex (SEC) family in transcriptional control. Luo Z, et al. Nat Rev Mol Cell Biol, 2012 Sep. PMID 22895430
    3. The little elongation complex regulates small nuclear RNA transcription. Smith ER, et al. Mol Cell, 2011 Dec 23. PMID 22195968, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein ENL
    Names
    myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
    translocated to, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106876.2 → NP_001100346.1  protein ENL

      See identical proteins and their annotated locations for NP_001100346.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6KQU1, M0R462
      Related
      ENSRNOP00000064141.2, ENSRNOT00000071211.2
      Conserved Domains (3) summary
      PRK10905
      Location:218 → 351
      PRK10905; cell division protein DamX; Validated
      cd16906
      Location:9 → 137
      YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins
      pfam17793
      Location:483 → 543
      AHD; ANC1 homology domain (AHD)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1818204..1863091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244307.5 → XP_006244369.1  protein ENL isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH62, M0R462
      Related
      ENSRNOP00000092239.1
      Conserved Domains (3) summary
      PRK10905
      Location:176 → 309
      PRK10905; cell division protein DamX; Validated
      cd16906
      Location:9 → 137
      YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins
      pfam17793
      Location:441 → 501
      AHD; ANC1 homology domain (AHD)

    2. XM_039083136.2 → XP_038939064.1  protein ENL isoform X2

      UniProtKB/TrEMBL
      M0R462
      Conserved Domains (3) summary
      PLN03237
      Location:125 → 381
      PLN03237; DNA topoisomerase 2; Provisional
      cl38902
      Location:36 → 80
      YEATS; YEATS domain family, chromatin reader proteins
      pfam17793
      Location:426 → 486
      AHD; ANC1 homology domain (AHD)
    Nucleotide Protein Strain
    Heading Accession and Version

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