U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Plaat1 phospholipase A and acyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288025, updated on 30-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Plaat1provided by RGD
    Official Full Name
    phospholipase A and acyltransferase 1provided by RGD
    Primary source
    RGD:1309485
    See related
    Ensembl:ENSRNOG00000001711 AllianceGenome:RGD:1309485
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    A-C1; HRSL1; RLP-2; Hrasls
    Summary
    Enables phospholipase activity. Predicted to be involved in glycerophospholipid metabolic process; lens fiber cell differentiation; and organelle disassembly. Predicted to act upstream of or within ether lipid metabolic process and peroxisome organization. Predicted to be located in several cellular components, including lysosome; nuclear envelope lumen; and peroxisome. Predicted to be active in cytoplasm. Orthologous to human PLAAT1 (phospholipase A and acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 190.0), Testes (RPKM 125.4) and 5 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    11q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (85022297..85041999, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (71517492..71537142, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (75125951..75145868, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552083 Neighboring gene ATPase 13A4 Neighboring gene ATPase 13A5 Neighboring gene CYLD lysine 63 deubiquitinase, pseudogene 2 Neighboring gene Mab-21 domain containing 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comparative analyses of isoforms of the calcium-independent phosphatidylethanolamine N-acyltransferase PLAAT-1 in humans and mice. Hussain Z, et al. J Lipid Res, 2016 Nov. PMID 27623847, Free PMC Article
    2. Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes. Shinohara N, et al. J Lipid Res, 2011 Nov. PMID 21880860, Free PMC Article
    3. Molecular cloning and biological activity of a novel Ha-Ras suppressor gene predominantly expressed in skeletal muscle, heart, brain, and bone marrow by differential display using clonal mouse EC cells, ATDC5. Akiyama H, et al. J Biol Chem, 1999 Nov 5. PMID 10542256
    4. Regulation of peroxisomal lipid metabolism by catalytic activity of tumor suppressor H-rev107. Uyama T, et al. J Biol Chem, 2012 Jan 20. PMID 22134920, Free PMC Article
    5. Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. Uyama T, et al. J Biol Chem, 2012 Sep 14. PMID 22825852, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a possible enzyme activity of A-C1
      Title: Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine 1-acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A1 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acylphosphatidylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acylphosphatidylethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ether lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lens fiber cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear envelope lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phospholipase A and acyltransferase 1
    Names
    HRAS-like suppressor 1
    LRAT-like protein-2
    phospholipid-metabolizing enzyme A-C1
    NP_001099341.1
    XP_006248572.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105871.2 → NP_001099341.1  phospholipase A and acyltransferase 1

      See identical proteins and their annotated locations for NP_001099341.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      D2KX21
      UniProtKB/TrEMBL
      A6JRW7
      Conserved Domains (1) summary
      pfam04970
      Location:26 → 130
      LRAT; Lecithin retinol acyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      85022297..85041999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248510.5 → XP_006248572.1  phospholipase A and acyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006248572.1

      UniProtKB/Swiss-Prot
      D2KX21
      UniProtKB/TrEMBL
      A6JRW7
      Related
      ENSRNOP00000002329.3
      Conserved Domains (1) summary
      pfam04970
      Location:26 → 130
      LRAT; Lecithin retinol acyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D2KX21.1 GenPept UniProtKB/Swiss-Prot:D2KX21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous