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    Blk BLK proto-oncogene, Src family tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364403, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Blkprovided by RGD
    Official Full Name
    BLK proto-oncogene, Src family tyrosine kinaseprovided by RGD
    Primary source
    RGD:1308859
    See related
    Ensembl:ENSRNOG00000010798 AllianceGenome:RGD:1308859
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of leukocyte proliferation; and regulation of leukocyte apoptotic process. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 11 and systemic lupus erythematosus. Orthologous to human BLK (BLK proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 119.7), Thymus (RPKM 28.5) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Blk in Genome Data Viewer
    Location:
    15p12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41802701..41841004, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (37626746..37665053, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46555552..46593778, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene GATA binding protein 4 Neighboring gene uncharacterized LOC102548615 Neighboring gene uncharacterized LOC120097012 Neighboring gene uncharacterized LOC120097013 Neighboring gene family with sequence similarity 167, member A Neighboring gene L-threonine dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Borowiec M, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19667185, Free PMC Article
    2. The effect of cardiac ischemic preconditioning on rat left ventricular gene expression profile. Canatan H. Cell Biochem Funct, 2008 Mar-Apr. PMID 17562528
    3. [Restoration of the function of bilateral hand grip at the expense of the fingers of the same hand]. Azolov VV. Ortop Travmatol Protez, 1977 Apr. PMID 876631
    4. Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population. Ito I, et al. Arthritis Rheum, 2009 Feb. PMID 19180478
    5. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Liu H, et al. Nature, 2018 Nov. PMID 30356214

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112647

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase Blk
    Names
    B lymphoid tyrosine kinase
    NP_001020922.1
    XP_006252250.1
    XP_038949478.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025751.1 → NP_001020922.1  tyrosine-protein kinase Blk

      See identical proteins and their annotated locations for NP_001020922.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098683
      UniProtKB/TrEMBL
      F7EWL4, Q4KM97
      Related
      ENSRNOP00000015021.4, ENSRNOT00000015021.7
      Conserved Domains (4) summary
      pfam07714
      Location:235 → 484
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:114 → 213
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:56 → 109
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:227 → 490
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      41802701..41841004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252188.4 → XP_006252250.1  tyrosine-protein kinase Blk isoform X1

      Conserved Domains (4) summary
      pfam07714
      Location:290 → 539
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:169 → 268
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:111 → 164
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:282 → 545
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039093550.2 → XP_038949478.1  tyrosine-protein kinase Blk isoform X2

      Conserved Domains (2) summary
      cl15255
      Location:1 → 78
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:92 → 355
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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