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    Trir telomerase RNA component interacting RNase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288920, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trirprovided by RGD
    Official Full Name
    telomerase RNA component interacting RNaseprovided by RGD
    Primary source
    RGD:1564093
    See related
    Ensembl:ENSRNOG00000003863 AllianceGenome:RGD:1564093
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564093
    Summary
    Predicted to enable 3'-5' exonuclease activity and 5'-3' exonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic and rRNA catabolic process. Orthologous to human TRIR (telomerase RNA component interacting RNase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 820.7), Kidney (RPKM 366.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trir in Genome Data Viewer
    Location:
    19q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40029952..40033368, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23125083..23128502, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26142720..26146136)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA ZL2 Neighboring gene transportin 2 Neighboring gene small nucleolar RNA, C/D box 41 Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene bestrophin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of an RNase that preferentially cleaves A/G nucleotides. Xie J, et al. Sci Rep, 2017 Mar 21. PMID 28322335, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5'-3' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    telomerase RNA component interacting RNase
    Names
    uncharacterized protein C19orf43 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105946.1 → NP_001099416.1  telomerase RNA component interacting RNase

      See identical proteins and their annotated locations for NP_001099416.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IY38, D3ZGR7
      Related
      ENSRNOP00000005270.2, ENSRNOT00000005270.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40029952..40033368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277833.1 → XP_063133903.1  telomerase RNA component interacting RNase isoform X2

    2. XM_063277832.1 → XP_063133902.1  telomerase RNA component interacting RNase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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